Chitin whisker liquid crystal hydrogel embedded with polyacrylic acid templating osteoid-like Bouligand structure for guiding internal mineralization

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
Ruixi Zhang , Yiting Luo , Wei Zhou , Xinxin Huang , Runshan Huang , Wei Wen , Shan Ding , Hong Li , Mingxian Liu , Changren Zhou , Binghong Luo
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Abstract

Sophisticated layered structure and organic/inorganic composition endow lamellar bone with exceptional mechanical properties, which are originated from the mineralization of osteoid with liquid crystal (LC) Bouligand structure under polyanion microenvironment. However, there are few reports focusing on the mechanism of LC phase guided mineralization, and constructing suitable LC models to explore osteoid mineralization remains a challenge. Here, we propose a novel LC hydrogel with Bouligand structure and rich in -COOH groups to simulate osteoid mineralization. Specifically, chitin whiskers (CHWs) co-assemble with polyacrylic acid (PAA) to form osteoid-like LC phase, which is crosslinked to prepare LC hydrogel with Bouligand structure. Using this LC hydrogel as a template to guide the mineralization of PAA-stabilized amorphous calcium phosphate (ACP), a bone ECM-like organic/inorganic composite is achieved. Due to the strengthening/toughening effect of Bouligand structure and formed calcium phosphates, the composite exhibits excellent mechanical properties. Creatively, LC template achieves effective internal mineralization under the synergetic guidance of Bouligand structure and PAA, moreover, there is differential mineralization inside/outside the LC template, which well mimics natural bone. This study first reveals the biomineralization mechanism and synergistic effect guided by Bouligand structure and PAA, providing an innovative idea for exploring the formation of lamellar bone.

Abstract Image

几丁质晶须液晶水凝胶内嵌聚丙烯酸模板状骨样布利甘结构,用于引导内部矿化
复杂的层状结构和有机/无机组成使板层骨具有优异的力学性能,这是在多阴离子微环境下形成的具有液晶(LC) Bouligand结构的类骨矿化所致。然而,关于LC相引导矿化机制的报道很少,构建合适的LC模型来探索类骨矿化仍然是一个挑战。在这里,我们提出了一种具有Bouligand结构和富含-COOH基团的新型LC水凝胶来模拟类骨矿化。具体而言,甲壳素晶须(chw)与聚丙烯酸(PAA)共组装形成类骨相,并通过交联制备具有Bouligand结构的LC水凝胶。使用该LC水凝胶作为模板,引导paa稳定的无定形磷酸钙(ACP)矿化,实现了骨ecm样有机/无机复合材料。由于Bouligand结构和形成的磷酸钙的强化/增韧作用,复合材料表现出优异的力学性能。创造性地,LC模板在Bouligand结构和PAA的协同引导下实现了有效的内部矿化,并且LC模板内外存在差异矿化,很好地模拟了天然骨。本研究首次揭示了Bouligand结构和PAA引导下的生物矿化机制和协同作用,为探索板层骨形成提供了创新思路。
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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