Ruixi Zhang , Yiting Luo , Wei Zhou , Xinxin Huang , Runshan Huang , Wei Wen , Shan Ding , Hong Li , Mingxian Liu , Changren Zhou , Binghong Luo
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引用次数: 0
Abstract
Sophisticated layered structure and organic/inorganic composition endow lamellar bone with exceptional mechanical properties, which are originated from the mineralization of osteoid with liquid crystal (LC) Bouligand structure under polyanion microenvironment. However, there are few reports focusing on the mechanism of LC phase guided mineralization, and constructing suitable LC models to explore osteoid mineralization remains a challenge. Here, we propose a novel LC hydrogel with Bouligand structure and rich in -COOH groups to simulate osteoid mineralization. Specifically, chitin whiskers (CHWs) co-assemble with polyacrylic acid (PAA) to form osteoid-like LC phase, which is crosslinked to prepare LC hydrogel with Bouligand structure. Using this LC hydrogel as a template to guide the mineralization of PAA-stabilized amorphous calcium phosphate (ACP), a bone ECM-like organic/inorganic composite is achieved. Due to the strengthening/toughening effect of Bouligand structure and formed calcium phosphates, the composite exhibits excellent mechanical properties. Creatively, LC template achieves effective internal mineralization under the synergetic guidance of Bouligand structure and PAA, moreover, there is differential mineralization inside/outside the LC template, which well mimics natural bone. This study first reveals the biomineralization mechanism and synergistic effect guided by Bouligand structure and PAA, providing an innovative idea for exploring the formation of lamellar bone.
期刊介绍:
Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience.
The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.