Sword and Board in One: A Bioinspired Nanocomposite Membrane for Guided Bone Regeneration

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Shuai Yuan, Yanhuizhi Feng, Haicheng Wang, Si‐Ming Chen, Jia‐Hao Li, Yin‐Bo Zhu, Shu‐Hong Yu, Zuolin Wang
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引用次数: 0

Abstract

Guided bone regeneration (GBR) faces far from a one‐dimensional challenge. It demands a multifunctional membrane to possess paradoxical but essential properties in sophisticated clinical scenarios. Drawing inspiration from natural biological structures and superior properties, through a combination of structure innovation and composition regulation, a multicomponent nacre‐inspired discontinuous Bouligand structure is devised and transcribed into a bioinspired Janus nanocomposite membrane with comprehensive properties for GBR, identical to “sword and board.” As a sword, our membrane can actively adapt to sharp bony ridges owing to high toughness, capture water molecules for fluid penetration, drive osteogenic expression, and kill bacteria. As a board, it can achieve superior mechanical strength to withstand external forces, passively maintain structural integrity for ingrowth barrier, while function as a passive substrate for cell adhesion and proliferation. Overall, the membrane with excellent mechanical properties and bio‐functions is the paradigm of the combinatorial design of component and structure. It achieves the contradictory yet prerequisite features in response to the current challenge and offers new hope to advance biomedical applications. Equally important, the fabrication of our multifunctional bioinspired membrane is mild, efficient, scalable, and thus is poised to inspire the design of a broader range of functional material systems.
剑与板合一:引导骨再生的生物启发纳米复合膜
引导骨再生(GBR)面临着远不是一维的挑战。它要求多功能膜在复杂的临床场景中具有矛盾但必要的特性。从天然生物结构和优越的性能中汲取灵感,通过结构创新和成分调节的结合,设计了一种多组分珠层启发的不连续布利甘结构,并将其转录成具有GBR综合性能的仿生Janus纳米复合膜,与“剑与板”相同。我们的膜就像一把剑,由于其高韧性,可以主动适应锋利的骨脊,捕获水分子使流体渗透,驱动成骨表达,杀死细菌。作为板,它可以获得优越的机械强度来承受外力,被动地保持结构完整性作为生长屏障,同时作为细胞粘附和增殖的被动基质。总体而言,该膜具有优异的力学性能和生物功能,是组件和结构组合设计的典范。它实现了应对当前挑战的矛盾而又前提的特性,为推进生物医学应用提供了新的希望。同样重要的是,我们的多功能生物激发膜的制造是温和的,高效的,可扩展的,因此准备激发更广泛的功能材料系统的设计。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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