{"title":"Sword and Board in One: A Bioinspired Nanocomposite Membrane for Guided Bone Regeneration","authors":"Shuai Yuan, Yanhuizhi Feng, Haicheng Wang, Si‐Ming Chen, Jia‐Hao Li, Yin‐Bo Zhu, Shu‐Hong Yu, Zuolin Wang","doi":"10.1002/adma.202504577","DOIUrl":null,"url":null,"abstract":"Guided bone regeneration (GBR) faces far from a one‐dimensional challenge. It demands a multifunctional membrane to possess paradoxical but essential properties in sophisticated clinical scenarios. Drawing inspiration from natural biological structures and superior properties, through a combination of structure innovation and composition regulation, a multicomponent nacre‐inspired discontinuous Bouligand structure is devised and transcribed into a bioinspired Janus nanocomposite membrane with comprehensive properties for GBR, identical to “sword and board.” As a sword, our membrane can actively adapt to sharp bony ridges owing to high toughness, capture water molecules for fluid penetration, drive osteogenic expression, and kill bacteria. As a board, it can achieve superior mechanical strength to withstand external forces, passively maintain structural integrity for ingrowth barrier, while function as a passive substrate for cell adhesion and proliferation. Overall, the membrane with excellent mechanical properties and bio‐functions is the paradigm of the combinatorial design of component and structure. It achieves the contradictory yet prerequisite features in response to the current challenge and offers new hope to advance biomedical applications. Equally important, the fabrication of our multifunctional bioinspired membrane is mild, efficient, scalable, and thus is poised to inspire the design of a broader range of functional material systems.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"17 1","pages":""},"PeriodicalIF":27.4000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adma.202504577","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Guided bone regeneration (GBR) faces far from a one‐dimensional challenge. It demands a multifunctional membrane to possess paradoxical but essential properties in sophisticated clinical scenarios. Drawing inspiration from natural biological structures and superior properties, through a combination of structure innovation and composition regulation, a multicomponent nacre‐inspired discontinuous Bouligand structure is devised and transcribed into a bioinspired Janus nanocomposite membrane with comprehensive properties for GBR, identical to “sword and board.” As a sword, our membrane can actively adapt to sharp bony ridges owing to high toughness, capture water molecules for fluid penetration, drive osteogenic expression, and kill bacteria. As a board, it can achieve superior mechanical strength to withstand external forces, passively maintain structural integrity for ingrowth barrier, while function as a passive substrate for cell adhesion and proliferation. Overall, the membrane with excellent mechanical properties and bio‐functions is the paradigm of the combinatorial design of component and structure. It achieves the contradictory yet prerequisite features in response to the current challenge and offers new hope to advance biomedical applications. Equally important, the fabrication of our multifunctional bioinspired membrane is mild, efficient, scalable, and thus is poised to inspire the design of a broader range of functional material systems.
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.