Polybrominated diphenyl ethers (PBDEs), Occupational Exposures and Thyroid Function among U.S. and Canadian Firefighters: A Cross-sectional Study.

Journal of occupational and environmental medicine Pub Date : 2025-06-05 DOI:10.1097/JOM.0000000000003477

Bonnie E Gould Rothberg, Alberto J Caban-Martinez, Dana Boyd Barr, Mark A Jara, Valentina Rodriguez, Paola Louzado Feliciano, Katerina M Santiago, Cynthia Campos Beaver, Erin N Kobetz-Kerman, Natasha Schaefer Solle

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Abstract

Objective: Evaluate the association between serum polybrominated diphenyl ether (PBDE) levels and thyroid anatomy and function in firefighters.

Methods: 259 firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.

Results: A positive relationship between PBDE-47 and triiodothyronine (p = 0.02) while an inverse relationship with free thyroxine (p = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size (p = 0.03) and nodule aggressiveness (p = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians (p = 0.01).

Conclusions: PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.

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多溴联苯醚（PBDEs），职业暴露和甲状腺功能在美国和加拿大消防员：一个横断面研究。

目的：探讨消防员血清多溴联苯醚（PBDE）水平与甲状腺解剖和功能的关系。方法：259名消防员提供血液样本并进行甲状腺超声检查。检测甲状腺功能和多溴二苯醚-47、-85、-99、-100、-153和-154 （ng/g脂质重量）的血清水平。超声检查证实其结构特征。使用多变量线性回归确定多溴二苯醚浓度与人口统计学/职业特征、甲状腺功能和甲状腺解剖指标之间的双变量关联。结果：PBDE-47与三碘甲状腺原氨酸呈正相关（p = 0.02），与游离甲状腺素呈负相关（p = 0.03）。PBDE-47与甲状腺结节大小（p = 0.03）和结节侵袭性（p = 0.02）呈负相关。PBDE-47在美国西部消防员中最高，在抽样的加拿大人中最低（p = 0.01）。结论：PBDE-47可能导致消防员甲状腺功能失调。多溴二苯醚-47的含量在北美各地有所不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of occupational and environmental medicine

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