Primary biliary cholangitis: A historical perspective from xanthomatous lesions to modern molecular biology.

Vasiliy Ivanovich Reshetnyak, Elena Vladimirovna Vinnitskaya, Igor Veniaminovich Maev
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引用次数: 0

Abstract

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by damage and loss of the epithelial lining of small intrahepatic bile ducts, leading to ductopenia and cholestasis. In advanced stages, this process results in cirrhosis and liver failure. The disease belongs to cholangiopathies. The review addressed historical questions concerning: The history of the first mention of this disease; how its nomenclature was formed; when specific serological tests were discovered and their importance in the diagnosis of PBC; the history of ursodeoxycholic and other bile acids for the treatment of PBC; and the significance of modern data on impaired bicarbonate production by cholangiocytes in the pathogenesis of PBC.

原发性胆管炎:从黄瘤病变到现代分子生物学的历史观点。
原发性胆管炎(PBC)是一种慢性胆汁淤积性肝病,其特征是肝内小胆管上皮内层的损伤和丧失,导致胆管减少和胆汁淤积。在晚期,这个过程会导致肝硬化和肝功能衰竭。本病属于胆管病。该综述涉及以下历史问题:首次提及该病的历史;它的命名法是如何形成的;发现特异性血清学检测的时间及其在PBC诊断中的重要性;熊去氧胆酸和其他胆汁酸治疗PBC的历史;以及胆管细胞产生碳酸氢盐受损在PBC发病机制中的现代数据的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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