Effect of Exercise on Regulating miRNA Expression in Brain Health and Diseases.

IF 3.6 3区生物学 Q1 BIOLOGY

Biology-Basel Pub Date : 2025-06-19 DOI:10.3390/biology14060729

Jian Zhang, Fengmei Gu, Anand Thirupathi

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Abstract

Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that understanding miRNA-mediated mechanisms during exercise may offer valuable insights into using exercise as a therapeutic approach for neurodegenerative diseases. The existing literature on exercise-induced molecular pathways often presents inherent biases, complicating the establishment of exercise-induced miRNAs as reliable biomarkers for various chronic conditions due to their variable expression at tissue, organ, and systemic levels. Specifically, miRNA expression can downregulate critical signaling pathways such as TGF-β, FOXO, and NOTCH, which are implicated in the progression of neurodegenerative diseases. Exercise can override this scenario by targeting the expression of these miRNAs. However, the link between exercise modality-induced benefits (types, intensity, and duration) and the miRNA expression in brain cells is poorly understood. Therefore, this review aims to discuss how exercise-mediated miRNA expression affects brain pathophysiology, particularly in the context of neurodegenerative diseases.

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运动对脑健康和疾病中miRNA表达的调节作用

体育锻炼诱导表观遗传修饰，显著影响一组小的非编码rna（称为mirna）的表达。这些变化可以提高运动表现并影响神经系统，这表明了解运动过程中mirna介导的机制可能为将运动作为神经退行性疾病的治疗方法提供有价值的见解。现有的关于运动诱导的分子途径的文献往往存在固有的偏差，使运动诱导的mirna作为各种慢性疾病的可靠生物标志物的建立复杂化，因为它们在组织、器官和系统水平上的表达是可变的。具体来说，miRNA的表达可以下调TGF-β、FOXO和NOTCH等关键信号通路，这些信号通路与神经退行性疾病的进展有关。运动可以通过靶向这些mirna的表达来克服这种情况。然而，运动方式诱导的益处（类型、强度和持续时间）与脑细胞中miRNA表达之间的联系尚不清楚。因此，本综述旨在讨论运动介导的miRNA表达如何影响脑病理生理，特别是在神经退行性疾病的背景下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biology-Basel Biological Science-Biological Science

CiteScore

5.70

自引率

4.80%

发文量

1618

审稿时长

11 weeks

期刊介绍： Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.