Eosinophil count and treatment response in COPD patients.

IF 1.2 Q4 RESPIRATORY SYSTEM

Lung India Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI:10.4103/lungindia.lungindia_630_24

C R Kiran, K Anitha Kumari, Sanjeev Nair, A Fathahudeen

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Abstract

Background and objective: Eosinophils are an integral part of lung defence against microbes. It is also responsible for untoward hyper immune responses responsible for lung diseases including Chronic Obstructive Pulmonary Disease (COPD). To compare COPD patients with high and low Absolute Eosinophil Count (AEC) regarding their frequency of exacerbations, and response to treatment.

Materials and methods: Prospective observational study. Patients were divided into 2 groups above and below the mean AEC and followed up for 6 months, during when their frequencies of exacerbations were followed up. At the end of 6 months, symptomatology and lung function were reassessed.

Results: Those with high AEC had a shorter time to first exacerbation. These patients also needed significantly greater number of inpatient admissions during the study period. Fall in FEV1 was also significantly higher in this group. There was no significant difference in changes in BMI, CAT or MMRC scores, between these groups.

Conclusion: Patients with high AEC are at higher risk of exacerbations, as well as loss of lung function.

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慢性阻塞性肺病患者嗜酸性粒细胞计数与治疗反应。

背景和目的：嗜酸性粒细胞是肺防御微生物的重要组成部分。它还会导致不良的超免疫反应，导致包括慢性阻塞性肺疾病（COPD）在内的肺部疾病。比较高和低绝对嗜酸性粒细胞计数（AEC）的COPD患者的急性发作频率和对治疗的反应。材料和方法：前瞻性观察研究。将患者分为平均AEC以上和低于平均AEC的2组，随访6个月，随访期间随访患者急性发作频率。6个月后，重新评估症状和肺功能。结果：AEC高的患者到首次加重的时间较短。这些患者在研究期间也需要大量的住院治疗。在这一组中，FEV1的下降也明显更高。两组之间的BMI、CAT或MMRC评分变化无显著差异。结论：高AEC患者急性加重及肺功能丧失的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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