A Global Perspective on Incidence and Regional Trends of Opioid Use Disorders From 1990 to 2021.

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI:10.30773/pi.2025.0039

Tiantian Tuo, Yupeng Chen, Danyang Wang, Jinna Liu, Yujiao Wu, Jiawen Wang

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引用次数: 0

Abstract

Objective: Opioid use disorders (OUDs) have become a significant global public health challenge. Despite extensive research on the opioid crisis, the trends in incidence and regional disparities remain inadequately understood.

Methods: Data were obtained from the Global Burden of Disease 2021, covering 204 countries and territories. OUDs incidence cases and rates per 100,000 population were analyzed over the study period. Trends were evaluated using the estimated annual percentage change (EAPC).

Results: Globally, OUDs cases increased by 49.25% from 1,301,551 (95% uncertainty interval [UI]: 1,077,634 to 1,598,053) in 1990 to 1,942,525 (95% UI: 1,643,342 to 2,328,363) in 2021. The incidence rate in 2021 was 24.62 per 100,000 population, with an EAPC of -0.25 (95% confidence interval: -0.39 to -0.1). Males had slightly higher rates than females (25.39 vs. 23.84 per 100,000). Individuals aged 15-49 years carried the highest burden, while older age groups showed the largest increases in cases. High-income North America reported the highest incidence rate in 2021 (123.28 per 100,000) and the largest case increase (425.34%). Among countries, the United States had the highest incidence rate increase (EAPC: 5.55), while Switzerland experienced the largest decline (EAPC: -4.33). A moderate positive correlation was identified between 2021 incidence rates and socio-demographic development (ρ=0.382, p<0.001).

Conclusion: This study highlights substantial global variability in OUDs trends, with significant differences across regions, sexes, age groups, and countries. Findings emphasize the need for tailored prevention and treatment strategies.

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1990年至2021年阿片类药物使用障碍发病率和区域趋势的全球视角

目的：阿片类药物使用障碍（OUDs）已成为一个重大的全球公共卫生挑战。尽管对阿片类药物危机进行了广泛的研究，但发病率的趋势和区域差异仍然没有得到充分的了解。方法：数据来自《2021年全球疾病负担》，涵盖204个国家和地区。在研究期间，分析了每10万人的OUDs发病率和发病率。使用估计的年百分比变化（EAPC）评估趋势。结果：在全球范围内，oud病例从1990年的1,301,551例（95%不确定区间[UI]: 1,077,634至1,598,053）增加到2021年的1,942,525例（95% UI: 1,643,342至2,328,363），增加了49.25%。2021年的发病率为每10万人24.62例，EAPC为-0.25（95%可信区间：-0.39至-0.1）。男性的发病率略高于女性（25.39比23.84 / 10万）。15-49岁的个体负担最重，而老年群体的病例增幅最大。高收入北美地区报告的2021年发病率最高（每10万人中有123.28人），病例增幅最大（425.34%）。在各国中，美国的发病率增长最高（EAPC: 5.55），而瑞士的发病率下降幅度最大（EAPC: -4.33）。2021年的发病率与社会人口发展之间存在中度正相关（ρ=0.382, p）。结论：该研究强调了OUDs趋势的全球变异性，在地区、性别、年龄组和国家之间存在显著差异。研究结果强调需要有针对性的预防和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.