Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections.

IF 6.9 1区 医学 Q1 IMMUNOLOGY
Maxime Taquet, John A Todd, Paul J Harrison
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引用次数: 0

Abstract

AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk.

预防带状疱疹和呼吸道合胞病毒感染的as01佐剂疫苗可降低痴呆风险。
as01佐剂带状疱疹疫苗与较低的痴呆风险相关,但其潜在机制尚不清楚。在436,788名个体的倾向评分匹配队列研究中,as01辅助带状疱疹和呼吸道合胞病毒(RSV)疫苗(单独或联合)与降低18个月痴呆风险相关。两种AS01佐剂疫苗之间没有观察到差异,这表明AS01佐剂本身在降低痴呆风险方面起直接作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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