Exploring frailty in dementia with Lewy bodies: A pilot, cross-sectional study.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI:10.1177/13872877251352076

Fabrizia D'Antonio, Massimiliano Panigutti, Alice Teghil, Marco Toccaceli Blasi, Martina Salzillo, Giusi Talarico, Micaela Sepe Monti, Giuseppe Bruno, Marco Canevelli

引用次数: 0

Abstract

We aimed to investigate frailty in dementia with Lewy bodies (DLB) and its association with its core features. We retrospectively reviewed the clinical charts of 48 DLB outpatients. Frailty Index (FI) was generated by computing 39 age-related, multidimensional clinical deficits. FI scores varied from 0.08 to 0.54, with a median value of 0.26. FI showed a correlation with the severity of parkinsonism and visuo-spatial impairment, suggesting that some DLB features might be more influenced by frailty, whereas others, such as visual hallucinations, fluctuations, REM-behavior-disorder, seem not. Frailty may contribute to phenotypic variability in DLB; this study could inform future research aimed at clarifying the role of frailty in DLB.

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探索衰弱与路易体痴呆：一个试点，横断面研究。

我们的目的是研究路易体痴呆（DLB）的虚弱及其与核心特征的关系。我们回顾性回顾了48例DLB门诊患者的临床资料。衰弱指数（FI）是通过计算39个与年龄相关的多维临床缺陷而产生的。FI评分范围为0.08 ~ 0.54，中位数为0.26。FI显示与帕金森病和视觉空间障碍的严重程度相关，这表明一些DLB特征可能更受虚弱的影响，而其他特征，如视觉幻觉、波动、快速眼动行为障碍似乎没有影响。虚弱可能导致DLB的表型变异；这项研究可以为未来旨在阐明虚弱在DLB中的作用的研究提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.