γδT Cells in IBD: Beneficial or Detrimental?

IF 4.9 3区医学 Q2 IMMUNOLOGY

Immunology Pub Date : 2025-06-25 DOI:10.1111/imm.70012

Baoqing Xu, Jianbin Ji, Lingling Ma, Chunyan Wang, Lianjing Pang, QingChao Song, Yang Liu, Zhenghua Zhou, Fanfan Qu

引用次数: 0

Abstract

γδT cells play a crucial role in inflammatory bowel disease (IBD). Studies have shown that the number, subsets and secreted cytokines of γδT cells undergo changes in IBD. However, whether γδT cells are beneficial or detrimental in IBD remains controversial. Some studies suggest that γδT cells have a protective role in colitis, while others indicate that the expansion and activation of γδT cells may exacerbate colitis. Several studies have explored γδT cell-based therapies for immune disorders, and γδT cell-based therapy for IBD has emerged as a promising research direction. There are numerous reviews of γδT cells and autoimmune diseases, but few reviews focus on γδT and IBD. Therefore, this article briefly summarises the current understanding of γδT cells in IBD.

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γδT细胞在IBD中的作用：有益还是有害？

γδT细胞在炎症性肠病（IBD）中起重要作用。研究表明，γδT细胞的数量、亚群和分泌的细胞因子在IBD中发生变化。然而，γδT细胞在IBD中是有益还是有害仍有争议。一些研究表明γδT细胞在结肠炎中具有保护作用，而另一些研究表明γδT细胞的扩增和活化可能加剧结肠炎。一些研究已经探索了以γδT细胞为基础的免疫疾病治疗方法，其中以γδT细胞为基础的IBD治疗已成为一个有前景的研究方向。关于γδT细胞与自身免疫性疾病的研究有很多，但关于γδT与IBD的研究很少。因此，本文就目前对IBD中γδT细胞的认识作一简要总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology 医学-免疫学

CiteScore

11.90

自引率

1.60%

发文量

175

审稿时长

4-8 weeks

期刊介绍： Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.