Effects of different peripheral fatigue protocol on lower limb biomechanical changes during landing and its impact on the risk of anterior cruciate ligament injury: a systematic review.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1587573
Zhanyang He, Gang Sun, Houwei Zhu, Binyong Ye, Zhe Zheng, Xiaolong He, Huiju Pan
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引用次数: 0

Abstract

Previous research suggests that although fatigue accumulates during competitions and at season's end, anterior cruciate ligament (ACL) injuries do not significantly increase, with peripheral fatigue-induced muscle weakness potentially playing a key role. The aim of this study is to systematically review the effects of different peripheral fatigue interventions on biomechanical variables associated with ACL injury risk during landing tasks. A systematic search was conducted in five databases Web of Science, Scopus, PubMed, EBSCO, and Cochrane Library up to September 2024. The evidence classification system was used to grade the evidence on lower limb biomechanical changes. A total of 12 studies, involving 217 participants (105 males, 112 females), were included. These studies examined 9 peripheral fatigue protocols, 14 kinematic variables, and 16 kinetic variables. Among the 14 kinematic variables reviewed, strong evidence indicates increased knee internal rotation angles at peak vertical ground reaction force (vGRF) during landing tasks after the knee flexors and extensors peripheral fatigue protocols (Effect size = 0.24-0.68). For the 16 kinetic variables reviewed, strong evidence only suggests a reduction in peak vGRF during landing tasks after knee flexors and extensors peripheral fatigue protocols (Effect size = 0.12-0.32). In conclusion, we found that only two peripheral fatigue interventions were supported by evidence, while most kinematic and kinetic variables showed conflicting results, underscoring the need for further research. Such improvements will help clarify whether current neuromuscular ACL injury prevention programs need to be adapted to account for the biomechanical changes brought about by peripheral fatigue. Systematic Review Registration: clinicaltrials.gov, identifier CRD42024593839.

不同外周疲劳方案对着陆过程中下肢生物力学变化的影响及其对前交叉韧带损伤风险的影响:系统综述。
先前的研究表明,尽管疲劳在比赛期间和赛季结束时积累,前交叉韧带(ACL)损伤并没有显著增加,周围疲劳引起的肌肉无力可能起着关键作用。本研究的目的是系统回顾不同外周疲劳干预对着陆任务中与前交叉韧带损伤风险相关的生物力学变量的影响。系统检索截至2024年9月的Web of Science、Scopus、PubMed、EBSCO和Cochrane Library 5个数据库。采用证据分类系统对下肢生物力学变化的证据进行分级。共纳入12项研究,涉及217名参与者(105名男性,112名女性)。这些研究检查了9个外周疲劳方案,14个运动学变量和16个动力学变量。在回顾的14个运动学变量中,强有力的证据表明,在膝关节屈肌和伸肌周围疲劳方案后,着陆任务中膝关节垂直地面反力(vGRF)峰值时膝关节内部旋转角度增加(效应值= 0.24-0.68)。对于16个动力学变量,强有力的证据表明,在膝关节屈肌和伸肌外周疲劳方案后,着陆任务期间vGRF峰值降低(效应值= 0.12-0.32)。总之,我们发现只有两种外周疲劳干预有证据支持,而大多数运动学和动力学变量显示了相互矛盾的结果,强调了进一步研究的必要性。这些改进将有助于澄清当前的神经肌肉前交叉韧带损伤预防方案是否需要适应外周疲劳带来的生物力学变化。系统评价注册:clinicaltrials.gov,编号CRD42024593839。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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