Development of a global forearm reconstruction system for post-tumor resection defects of the radius or ulna: a proof-of-concept study.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1547652

Haijie Liang, Jie Zang, Siyi Huang, Boyang Wang, Shun Tang, Zhiye Du, Feiyang Qi, Wei Guo, Jichuan Wang, Xiaodong Tang

{"title":"Development of a global forearm reconstruction system for post-tumor resection defects of the radius or ulna: a proof-of-concept study.","authors":"Haijie Liang, Jie Zang, Siyi Huang, Boyang Wang, Shun Tang, Zhiye Du, Feiyang Qi, Wei Guo, Jichuan Wang, Xiaodong Tang","doi":"10.3389/fbioe.2025.1547652","DOIUrl":null,"url":null,"abstract":"Background: Bone defects resulting from sarcoma resection in the forearm present significant challenges for reconstruction, with limited guidance available in the literature.Methods: We developed a novel series of 3D-printed endoprostheses, called the Global Forearm Reconstruction System (GFRS), to reconstruct defects of the proximal radius (PR), distal ulna (DU), total ulna (TU), and total radius (TR). Finite element analysis (FEA) was performed to determine the mechanical support function of the GFRS endoprostheses. We also tested the rotatory function of the endoprostheses ex vivo using a resin model. Finally, we summarized the preliminary outcomes of three pediatric cases using the GFRS endoprostheses for reconstruction.Results: Resection of PR, DU, TU and TR leads to stress concentration in the remaining structures, which can be mitigated by the corresponding GFRS endoprostheses. The novel endoprostheses demonstrated full supination capability and approximately 50% of pronation in the ex vivo model. All of the three clinical cases achieved satisfactory functional status (MSTS-93:28-29; MEPS: 95-100) without complications during mid-term follow-up (32-42 months).Conclusion: In this proof-of-concept study, we demonstrated that the GFRS endoprostheses not only meet the theoretical reconstruction requirements but also exhibit a good safety profile and produce satisfactory functional outcomes in a preliminary cohort with mid-term follow-up.","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1547652"},"PeriodicalIF":4.3000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187641/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1547652","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Bone defects resulting from sarcoma resection in the forearm present significant challenges for reconstruction, with limited guidance available in the literature.

Methods: We developed a novel series of 3D-printed endoprostheses, called the Global Forearm Reconstruction System (GFRS), to reconstruct defects of the proximal radius (PR), distal ulna (DU), total ulna (TU), and total radius (TR). Finite element analysis (FEA) was performed to determine the mechanical support function of the GFRS endoprostheses. We also tested the rotatory function of the endoprostheses ex vivo using a resin model. Finally, we summarized the preliminary outcomes of three pediatric cases using the GFRS endoprostheses for reconstruction.

Results: Resection of PR, DU, TU and TR leads to stress concentration in the remaining structures, which can be mitigated by the corresponding GFRS endoprostheses. The novel endoprostheses demonstrated full supination capability and approximately 50% of pronation in the ex vivo model. All of the three clinical cases achieved satisfactory functional status (MSTS-93:28-29; MEPS: 95-100) without complications during mid-term follow-up (32-42 months).

Conclusion: In this proof-of-concept study, we demonstrated that the GFRS endoprostheses not only meet the theoretical reconstruction requirements but also exhibit a good safety profile and produce satisfactory functional outcomes in a preliminary cohort with mid-term follow-up.

查看原文本刊更多论文

一种用于肿瘤切除后桡骨或尺骨缺损的整体前臂重建系统的开发：概念验证研究。

背景：前臂肉瘤切除术导致的骨缺损对重建提出了重大挑战，文献中可获得的指导有限。方法：我们开发了一系列新的3d打印内假体，称为全球前臂重建系统（GFRS），用于重建桡骨近端（PR），远端尺骨（DU），总尺骨（TU）和总桡骨（TR）的缺陷。采用有限元分析（FEA）确定GFRS内假体的机械支撑功能。我们还使用树脂模型测试了体外假体的旋转功能。最后，我们总结了三例使用GFRS内假体进行重建的儿童病例的初步结果。结果：切除PR、DU、TU和TR导致剩余结构应力集中，可通过相应的GFRS内假体缓解。在离体模型中，新型内假体显示出完全的旋后能力和大约50%的旋前能力。3例患者均达到满意的功能状态(MSTS-93:28-29；中期随访（32 ~ 42个月）MEPS: 95 ~ 100)无并发症。结论：在这项概念验证研究中，我们在初步队列和中期随访中证明了GFRS内假体不仅满足理论重建要求，而且具有良好的安全性和令人满意的功能结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.