Delirium Severity Trajectories in Critically Ill Adults Using the Intensive Care Delirium Screening Checklist: A Population-Based Cohort.

IF 6 1区 医学 Q1 CRITICAL CARE MEDICINE
Critical Care Medicine Pub Date : 2025-09-01 Epub Date: 2025-06-26 DOI:10.1097/CCM.0000000000006768
Heidi Lindroth, Kirsten M Fiest, Chel Hee Lee, Kenny Adefila, Janelle Boram Lee, Sikandar Khan, Babar A Khan, Malaz A Boustani, Karla D Krewulak
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引用次数: 0

Abstract

Objectives: The delirium course of critically ill adults can be classified into trajectories based on the severity and duration of delirium as shown by a recent study. It is unknown whether these trajectories and associated outcomes are reproducible. We aimed to define delirium severity trajectories using the Intensive Care Delirium Screening Checklist (ICDSC) and delirium duration and evaluate the association of trajectory membership with clinical characteristics and 30-day post-discharge mortality.

Design: Population-based retrospective cohort.

Setting: Fourteen medical-surgical ICUs in Alberta, Canada from January 1, 2014, to December 21, 2019.

Patients: We included adult patients (≥ 18 yr old) with an ICU length of stay of greater than or equal to 24 hours, an ICDSC score indicating delirium (≥ 4), and 30-day follow-up data were included. Group-based trajectory modeling identified trajectories over a 7-day period with SAS v9.4 (SAS Institute, Cary, NC).

Interventions: None.

Measurements and main results: Demographic (age, sex) and clinical data (2 × d ICDSC score, comorbidities, illness severity, admission reason, procedures, length of stay, in-hospital, and 30-d post-discharge mortality) were captured from electronic medical records. In total, 21,071 patients were included, with a median age of 59 years (interquartile range, 46-70 yr), 59% male ( n = 12,547), and 3% died at 30 days ( n = 541). The five-trajectory model was selected. These trajectories followed previously defined patterns: 1) Mild-Brief (19.4%); 2); Severe-Rapid Recovers (18.5%); 3) Severe-Slow Recovers (31%); 4) Mild-Accelerating (14.1%); and 5) Severe-Nonrecovers (16.9%). Trajectory membership was not significantly associated with 30-day post-discharge mortality; however, clinically relevant trends were observed.

Conclusions: The current study substantiates the proof-of-concept model of five delirium severity trajectories. Trajectory membership did not predict 30-day post-discharge mortality. Further research is needed to understand the associations between trajectory membership, biological-based biomarkers, and patient-relevant outcomes.

使用重症监护谵妄筛查清单的危重成人谵妄严重程度轨迹:基于人群的队列。
目的:最近的一项研究表明,危重症成人谵妄病程可以根据谵妄的严重程度和持续时间划分为不同的轨迹。目前尚不清楚这些轨迹和相关结果是否可重复。我们旨在使用重症监护谵妄筛查清单(ICDSC)和谵妄持续时间定义谵妄严重程度轨迹,并评估轨迹成员与临床特征和出院后30天死亡率的关系。设计:基于人群的回顾性队列。环境:2014年1月1日至2019年12月21日,加拿大艾伯塔省14个内科外科icu。患者:我们纳入了ICU住院时间大于或等于24小时的成人患者(≥18岁),ICDSC评分表明谵妄(≥4),并纳入了30天的随访数据。使用SAS v9.4 (SAS Institute, Cary, NC),基于组的轨迹建模确定了7天内的轨迹。干预措施:没有。测量方法和主要结果:从电子病历中获取人口统计学(年龄、性别)和临床数据(2 × d ICDSC评分、合并症、疾病严重程度、入院原因、程序、住院时间、住院和出院后30 d死亡率)。总共纳入21071例患者,中位年龄为59岁(四分位数范围为46-70岁),59%为男性(n = 12547), 3%在30天内死亡(n = 541)。选择五轨迹模型。这些轨迹遵循先前定义的模式:1)温和-短暂(19.4%);2);快速恢复(18.5%);3)严重缓慢恢复(31%);4)温和加速(14.1%);5)严重-不恢复(16.9%)。轨迹成员与出院后30天死亡率无显著相关;然而,观察到临床相关的趋势。结论:目前的研究证实了五种谵妄严重程度轨迹的概念验证模型。轨迹成员不能预测出院后30天的死亡率。需要进一步的研究来了解轨迹成员、基于生物学的生物标志物和患者相关结果之间的关系。
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来源期刊
Critical Care Medicine
Critical Care Medicine 医学-危重病医学
CiteScore
16.30
自引率
5.70%
发文量
728
审稿时长
2 months
期刊介绍: Critical Care Medicine is the premier peer-reviewed, scientific publication in critical care medicine. Directed to those specialists who treat patients in the ICU and CCU, including chest physicians, surgeons, pediatricians, pharmacists/pharmacologists, anesthesiologists, critical care nurses, and other healthcare professionals, Critical Care Medicine covers all aspects of acute and emergency care for the critically ill or injured patient. Each issue presents critical care practitioners with clinical breakthroughs that lead to better patient care, the latest news on promising research, and advances in equipment and techniques.
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