A Novel Concept of the "Standard Human" in the Assessment of Individual Total Heart Size: Lessons from Non-Contrast-Enhanced Cardiac CT Examinations.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Maciej Sosnowski, Zofia Parma, Marcin Syzdół, Grzegorz Brożek, Jan Harpula, Michał Tendera, Wojciech Wojakowski
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引用次数: 0

Abstract

Background: This single-center retrospective observational study reviewed data from 2305 persons examined for coronary artery calcium (CAC) with non-contrast-enhanced cardiac CT. Other cardiac structures, including chamber volumes, were evaluated besides the CAC scoring. We proposed a novel body size indexing measure that may outperform common indices for quantifying total heart volume (THV). Methods: This index is the sum of height and the difference between height (unitless) and body surface area (unitless), [h+(h-BSA)], and if the (h-BSA) equals "zero", it is a feature of the "standard human". Results: We found that, in subjects with a low cardiovascular (CV) risk, the THV normalized for the novel index was simply a function of BW gain, being the highest in obese. If high-CV-risk features (hypertension, diabetes) were present, the measured THV was larger than expected for BW gain, exceeding values observed in low-CV-risk ones. Differences were found to be sex-independent in all BMI categories. Conclusions: Common BSA correction hides these differences and makes the prognostication of CV risk error-introducing. The indexation we proposed might help distinguish the effects of body weight gain from the ones resulting from the presence of certain cardiovascular diseases.

个人心脏总尺寸评估中“标准人”的新概念:来自非增强心脏CT检查的经验教训。
背景:这项单中心回顾性观察性研究回顾了2305名使用非增强心脏CT检查冠状动脉钙化(CAC)的患者的数据。除CAC评分外,还评估其他心脏结构,包括腔室容积。我们提出了一种新的身体尺寸指数测量,可能优于量化总心脏容积(THV)的常用指标。方法:该指标为身高与身高(无单位)与体表面积(无单位)之差之和[h+(h- bsa)],如果(h- bsa)等于“零”,则为“标准人”的特征。结果:我们发现,在心血管(CV)风险较低的受试者中,新指数归一化的THV仅仅是体重增加的函数,在肥胖人群中最高。如果存在高危特征(高血压、糖尿病),体重增加的THV测量值大于预期值,超过低危人群观察到的值。在所有BMI类别中,差异都是与性别无关的。结论:普通的BSA校正掩盖了这些差异,并使CV风险的预测引入错误。我们提出的指数可能有助于区分体重增加的影响与某些心血管疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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