19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Shota Iwata, Takuji Iwashita, Yosuke Ohashi, Akihiko Senju, Ryuichi Tezuka, Shinya Uemura, Kensaku Yoshida, Akinori Maruta, Yuhei Iwasa, Mitsuru Okuno, Keisuke Iwata, Tatsuhiko Miyazaki, Masahito Shimizu
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引用次数: 0

Abstract

Background/Objectives: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a useful procedure for obtaining histological specimens. However, its utility in diagnosing autoimmune pancreatitis (AIP) has not yet been well studied. This study aimed to assess the diagnostic capability of EUS-FNB for AIP by comparing a 19-gauge Franseen needle (19FR) and a 22-gauge Franseen needle (22FR). Methods: This study included patients with a final diagnosis of AIP undergoing EUS-FNB for pancreatic lesions between January 2014 and February 2023. All patients underwent EUS-FNB with either 19FR or 22FR. Histological findings were evaluated according to the International Consensus Diagnostic Criteria (ICDC). The primary outcome was the diagnostic yield of Level 1 (≥3 ICDC items) or Level 2 (2 ICDC items). Results: The 19FR group included 31 patients, and the 22FR group included 36 patients. The Level 1 diagnostic rate was significantly higher in the 19FR group than in the 22FR group (90.3% vs. 61.1%, p = 0.010). No significant difference was observed in the Level 2 diagnostic rate. The 19FR group yielded significantly larger histological tissue samples than the 22FR group (median area: 9.19 mm2/session vs. 3.36 mm2/session, p < 0.001). The analysis demonstrated a positive correlation between tissue area and the number of histological diagnostic items obtained. Conclusions: EUS-FNB performed with the 19FR provided larger histological specimens and a higher histological diagnostic yield than the 22FR in the diagnosis of AIP. Obtaining a larger amount of tissue may facilitate a definitive diagnosis of AIP.

超声内镜引导下细针活检对自身免疫性胰腺炎组织学诊断能力的比较:一项多中心回顾性队列研究
背景/目的:内镜超声引导下细针活检(EUS-FNB)是一种获取组织学标本的有效方法。然而,它在诊断自身免疫性胰腺炎(AIP)中的应用尚未得到很好的研究。本研究旨在通过比较19号fransee针(19FR)和22号fransee针(22FR)来评估EUS-FNB对AIP的诊断能力。方法:本研究纳入2014年1月至2023年2月期间接受EUS-FNB治疗胰腺病变最终诊断为AIP的患者。所有fr为19FR或22FR的患者均行EUS-FNB。根据国际共识诊断标准(ICDC)对组织学结果进行评估。主要终点为1级(≥3个ICDC项目)或2级(2个ICDC项目)的诊断率。结果:19FR组31例,22FR组36例。19FR组的一级诊断率显著高于22FR组(90.3% vs. 61.1%, p = 0.010)。2级诊断率差异无统计学意义。19FR组获得的组织学组织样本明显大于22FR组(中位面积:9.19 mm2/次vs. 3.36 mm2/次,p < 0.001)。分析表明,组织面积和获得的组织学诊断项目的数量呈正相关。结论:与22FR相比,19FR行EUS-FNB诊断AIP的组织学标本更大,组织学诊断率更高。获得更大量的组织可能有助于明确诊断AIP。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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