Exploring the neural mechanisms of ADHD in children: a multifeature cross-task fNIRS analysis.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Mengxiang Chu, Jiaojiao Ren, Lijuan Yang, Yunxiang Ma, Zhengyu Zhong, Xiaowei He, Hongbo Guo, Xiao Li, Jingjing Yu, Zhaohui Wang
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Abstract

Children with attention-deficit hyperactivity disorder exhibit multidimensional abnormalities of brain function, and the identification of key brain regions is often inconsistent across studies due to the influence of specific cognitive demands and feature selection. We conducted multifeature cross-task analysis and correlation analysis of functional near-infrared spectroscopy-based functional activity and connectivity under both resting state and verbal fluency task. Results reveal that more pronounced brain activation differences were observed in the right hemisphere of attention-deficit hyperactivity disorder group compared with healthy controls, particularly in channels 7 and 13, with cross-task consistent activation patterns. The strongest connectivity appeared between the right dorsolateral prefrontal cortex and the right frontopolar cortex in both resting state and verbal fluency task. Meanwhile, the task-related significant differences were mainly found in the left hemisphere, with fewer connectivity differences between tasks than between groups. Furthermore, a complex nonlinear relationship was identified between brain activation intensity and functional connectivity in attention-deficit hyperactivity disorder, a negative correlation in resting state, and a positive correlation in half of the brain regions (including bilateral dorsolateral prefrontal cortex) during verbal fluency task. These findings support the existing attention-deficit hyperactivity disorder mechanisms and supplement the complexity of cross-task brain functional reorganization and fixed functional abnormalities, thereby advancing research on the neurobiological basis of attention-deficit hyperactivity disorder.

探讨儿童ADHD的神经机制:多特征跨任务fNIRS分析。
注意缺陷多动障碍儿童表现出多方面的脑功能异常,由于特定认知需求和特征选择的影响,不同研究对大脑关键区域的识别往往不一致。我们对静息状态和言语流畅性任务下基于功能近红外光谱的功能活动和连通性进行了多特征跨任务分析和相关性分析。结果表明,与健康对照组相比,注意缺陷多动障碍组右半球的脑激活差异更明显,特别是在7通道和13通道,具有跨任务一致的激活模式。在静息状态和言语流畅性任务中,右背外侧前额叶皮层和右额极皮层之间的连通性最强。与此同时,任务相关的显著差异主要出现在左半球,任务间的连通性差异小于组间。此外,注意缺陷多动障碍的脑激活强度与功能连通性之间存在复杂的非线性关系,在静息状态下呈负相关,而在言语流畅性任务中,有一半的脑区(包括双侧背外侧前额叶皮层)呈正相关。这些发现支持了现有的注意缺陷多动障碍机制,补充了跨任务脑功能重组和固定功能异常的复杂性,从而推进了注意缺陷多动障碍的神经生物学基础研究。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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