Relationship of Intestinal Ultrasound with Clinical, Biochemical, And Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-06-26 DOI:10.14309/ctg.0000000000000881

Phillip Gu, David Ziring, Puja V Khanna, Waseem Ahmed, Eric Vasiliauskas, Andres Yarur, Stephan Targan, Dermot Pb McGovern, Shervin Rabizadeh, Phillip Fleshner, Maria T Abreu, Gil Y Melmed

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引用次数: 0

Abstract

Background: The utility of intestinal ultrasound (IUS) for ASUC is understudied. We correlated IUS to clinical, biochemical, and endoscopic disease severity in ASUC.

Method: In a blinded, prospective study of 20 ASUC subjects, we analyzed standard IUS parameters (bowel wall thickening, vascular flow, wall stratification) and UC IUS indices (IBUS-SAS, Milan-UC, UC-IUS) alongside modified Mayo symptoms scores, C-reactive protein (CRP), albumin, and UC endoscopic index of severity (UCEIS). Spearman correlations were performed (rs). Areas under the curve (AUC) determined utility of IUS for detecting severe endoscopic disease.

Results: All IUS indices correlated with stool frequency (rs:0.45-0.58, p<0.001), CRP (rs:0.56-0.59, p<0.02), and UCEIS (rs:0.54-0.69, p<0.03). IBUS-SAS (AUC 0.91) and Milan-UC (AUC 0.93) outperformed IUS-UC (AUC 0.82) for detecting UCEIS>5. Loss of bowel wall stratification correlated strongest with CRP (rs: 0.8, p=3.61e-8) and UCEIS (rs: 0.50, p=0.047).

Conclusion: IUS offers an accurate and non-invasive method to evaluate ASUC severity and treatment response.

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肠超声与急性重度溃疡性结肠炎临床、生化和内镜下疾病严重程度的关系：一项盲法、前瞻性研究

背景：肠道超声（IUS）在ASUC中的应用研究尚不充分。我们将IUS与ASUC的临床、生化和内窥镜疾病严重程度联系起来。方法：在一项对20名ASUC受试者的盲法前瞻性研究中，我们分析了标准IUS参数（肠壁增厚、血管流动、肠壁分层）和UC IUS指数（IBUS-SAS、Milan-UC、UC-IUS）以及改良的Mayo症状评分、c反应蛋白（CRP）、白蛋白和UC内镜严重程度指数（UCEIS）。Spearman相关（rs）。曲线下面积（AUC）决定了IUS在检测严重内窥镜疾病中的效用。结果：所有IUS指标与大便频率相关(rs:0.45 ~ 0.58, p5；肠壁分层丧失与CRP （rs: 0.8, p=3.61e-8）和UCEIS （rs: 0.50, p=0.047）相关性最强。结论：IUS提供了一种准确、无创的评估ASUC严重程度和治疗反应的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.