Nausea and Gastric Myoelectrical Activity are Influenced by Hormonal Contraception in Chronic Gastroduodenal Disorders.

IF 3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Alexandria H Lim, Chris Varghese, Gabrielle Sebaratnam, Gabriel Schamberg, Stefan Calder, Armen Gharibans, Christopher N Andrews, Charlotte Daker, Daphne Foong, Vincent Ho, Michelle R Wise, Gregory O'Grady
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引用次数: 0

Abstract

Background: Chronic gastroduodenal disorders are more prevalent among young women, many of whom are hormonal contraception users. We aimed to evaluate the effects of hormonal contraception on symptom severity and gastric myoelectrical activity in people with chronic gastroduodenal disorders.

Methods: This analysis was conducted on a large international cohort of patients who met Rome IV criteria for CNVS or FD and had undergone body surface gastric mapping using Gastric Alimetry (Alimetry, New Zealand). Symptoms were continuously reported on 0-10 Likert scales using a validated symptom logging app.

Results: One hundred twenty-seven people were included: 43 females using hormonal contraception, 30 not using hormonal contraception, 30 postmenopausal females, and 24 males. Hormonal contraception users had higher nausea than non-users (3.80 [IQR 2.00-5.42] vs 2.25 [0.20-4.43]; p<0.05), particularly when using combined oral contraceptives with hormone-free intervals compared to continuous use (5.20 [4.30-6.00] vs. 2.40 [1.70-3.80], p=0.02). Premenopausal women were more symptomatic than postmenopausal women and men (p<0.001). Principal Gastric Frequency was higher in hormonal contraception users (median 3.1cpm vs. 3.00cpm, p<0.001), and highest with progestogen-only formulations (p<0.02).

Conclusion: Women with gastroduodenal disorders on hormonal contraception experience increased nausea in comparison to non-users, with substantial variation dependent on contraceptive type. Hormonal contraception users also demonstrated modified gastric electrophysiology. These results imply that non-hormonal contraceptive alternatives should be trialled as a means to reduce symptoms in gastroduodenal disorders.

慢性胃十二指肠疾病患者的恶心和胃肌电活动受激素避孕的影响。
背景:慢性胃十二指肠疾病在年轻女性中更为普遍,其中许多人使用激素避孕。我们的目的是评估激素避孕对慢性胃十二指肠疾病患者症状严重程度和胃肌电活动的影响。方法:本分析是在一个大型国际队列患者中进行的,这些患者符合CNVS或FD的Rome IV标准,并使用胃Alimetry (Alimetry,新西兰)进行了体表胃测图。使用经过验证的症状记录应用程序以0-10李克特量表连续报告症状。结果:纳入127人:43名使用激素避孕的女性,30名未使用激素避孕的女性,30名绝经后女性和24名男性。使用激素避孕药者恶心程度高于未使用激素避孕药者(3.80 [IQR 2.00-5.42] vs 2.25 [0.20-4.43]);结论:与未使用激素避孕的女性相比,服用激素避孕的胃十二指肠疾病患者恶心程度增加,且根据避孕方式的不同有很大差异。激素避孕药使用者也表现出胃电生理的改变。这些结果表明,非激素避孕替代品应试验作为一种手段,以减轻胃十二指肠疾病的症状。
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来源期刊
Clinical and Translational Gastroenterology
Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.00
自引率
0.00%
发文量
114
审稿时长
16 weeks
期刊介绍: Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.
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