Sara Gargiulo, Lidovina Vecchiarelli, Eleonora Pagni, Matteo Gramanzini
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引用次数: 0
Abstract
Introduction: Chemotherapy is a primary treatment option in human and veterinary oncology. Like humans, canine patients often develop drug resistance. Comparative oncology is gaining increasing interest, and spontaneous tumors of companion dogs have emerged as a powerful resource for better understanding human cancer. The genetic, molecular, and histological features of tumors in dogs are more closely related to those in humans than the ones in laboratory animals, including complex mechanisms of drug resistance.
Methods: A comprehensive literature search was conducted in the electronic database Clarivate Web of Science (WOS): Medical Literature Analysis and Retrieval System Online (MEDLINE) from 1990 to 2025 (updated 22 January 2025). The final set includes 59 relevant full-text English articles.
Results: The literature findings suggest that canine spontaneous tumors are valuable model systems with important translational implications for identifying novel mechanisms of chemotherapy resistance shared with humans and may help advance the current standard of care in precision medicine.
Conclusions: We have provided an updated overview of the role of canine tumor models to study oncotherapy resistance, focusing on limitations and opportunities for advancement. Despite complementary benefits of such models in translational oncology research, their relevance remains underestimated. Strengthening the collaboration between human and veterinary medicine professionals and comparative medicine researchers, and obtaining the support of interdisciplinary institutions, could contribute to addressing the problem of multidrug resistance for both human and canine patients. Future research may promote using canine spontaneous tumors as translational therapeutic models for human chemoresistance, through a multidisciplinary approach based on the emerging "One Health, One Medicine" paradigm.
简介：化疗是人类和动物肿瘤的主要治疗选择。和人类一样，犬类病人也经常产生耐药性。比较肿瘤学正在获得越来越多的兴趣，而伴侣犬的自发性肿瘤已经成为更好地了解人类癌症的有力资源。与实验动物相比，狗体内肿瘤的遗传、分子和组织学特征与人类更接近，包括复杂的耐药机制。方法：对电子数据库Clarivate Web of Science (WOS): Medical literature Analysis and Retrieval System Online (MEDLINE) 1990 - 2025年（更新日期为2025年1月22日）进行全面的文献检索。最后一套包括59篇相关的英文全文文章。结果：文献结果表明，犬自发性肿瘤是有价值的模型系统，对识别与人类相同的化疗耐药新机制具有重要的转化意义，并可能有助于提高当前精准医学的护理标准。结论：我们提供了犬肿瘤模型在研究肿瘤治疗耐药中的作用的最新概述，重点是局限性和发展机会。尽管这些模型在转化肿瘤学研究中具有互补的好处，但它们的相关性仍然被低估。加强人兽医学专业人员和比较医学研究人员之间的合作，并获得跨学科机构的支持，将有助于解决人类和犬类患者的多药耐药问题。未来的研究可能会通过基于新兴的“同一健康，同一药物”范式的多学科方法，促进犬自发性肿瘤作为人类化疗耐药的转化治疗模型。
期刊介绍：
Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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