Unravelling the Adiponectin Hallmark and Exploring the Therapeutic Potential of Its Receptor Agonists in Cancer Metabolic Reprogramming.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2025-06-05 DOI:10.3390/biom15060820
Sanober Kafeel, Giuseppina Palmiero, Alessia Salzillo, Angela Ragone, Silvio Naviglio, Luigi Sapio
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引用次数: 0

Abstract

As the most abundant fat-derived hormone, adiponectin plays an essential role in regulating energy homeostasis. Current evidence proposes the serum levels of adiponectin as a risk factor and a diagnostic/prognostic biomarker in cancer. Moreover, distinctive antineoplastic features have also been reported as a result of adiponectin supplementation in preclinical models. Mapping of the cancer-associated metabolic changes has elucidated a highly adaptable and interconnected system that allows malignant cells to sustain their growth and survival. Along with the pyruvate into acetyl-CoA conversion, downregulation of both lactate dehydrogenase and glycolysis-related genes depicts the main adiponectin-induced perturbations affecting glucose metabolism in cancer. Meanwhile, a multi-level approach involving lipid trafficking, catabolism, and de novo synthesis has been attributed to adiponectin in malignancies. The adiponectin receptor agonist AdipoRon has recently been recognized as a promising antineoplastic compound. Remarkably, AdipoRon-mediated changes in cancer metabolism occur together with its antiproliferative potential. This review aimed at recapitulating the modulatory effects of adiponectin, as well as those of its synthetic receptor agonists, in driving metabolic alterations in cancerous cells. A critical discussion is also conducted to deduce whether the adiponectin axis could serve as a putative target to address the metabolic reprogramming in cancer progression.

揭示脂联素特征及其受体激动剂在癌症代谢重编程中的治疗潜力。
脂联素是最丰富的脂肪源性激素,在调节能量稳态中起重要作用。目前的证据表明,血清脂联素水平是癌症的危险因素和诊断/预后生物标志物。此外,在临床前模型中补充脂联素也报道了独特的抗肿瘤特征。癌症相关代谢变化的图谱已经阐明了一个高度适应性和相互关联的系统,该系统允许恶性细胞维持其生长和生存。随着丙酮酸转化为乙酰辅酶a,乳酸脱氢酶和糖酵解相关基因的下调描述了影响癌症中糖代谢的主要脂联素诱导的扰动。同时,脂联素在恶性肿瘤中的作用涉及脂质转运、分解代谢和新生合成等多层次途径。脂联素受体激动剂AdipoRon最近被认为是一种有前途的抗肿瘤化合物。值得注意的是,脂肪素介导的癌症代谢变化与其抗增殖潜能一起发生。本综述旨在概述脂联素及其合成受体激动剂在驱动癌细胞代谢改变中的调节作用。一个关键的讨论也进行了推断是否脂联素轴可以作为一个假定的目标,以解决癌症进展中的代谢重编程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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