Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective.

IF 3.8 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Bruna Silva, Marco Domingos, Sandra Amado, Juliana R Dias, Paula Pascoal-Faria, Ana C Maurício, Nuno Alves
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引用次数: 0

Abstract

Understanding the complex mechanical behavior of osteochondral tissues in silico is essential for improving experimental models and advancing research in joint health and degeneration. This review provides a comprehensive analysis of the constitutive models currently used to represent the different layers of the osteochondral region, from articular cartilage to subchondral bone, including intermediate regions such as the tidemark and the calcified cartilage layer. Each layer exhibits unique structural and mechanical properties, necessitating a layer-specific modeling approach. Through critical comparison of existing mathematical models, the viscoelastic model is suggested as a pragmatic starting point for modeling articular cartilage zones, the tidemark, and the calcified cartilage layer, as it captures essential time-dependent behaviors such as creep and stress relaxation while ensuring computational efficiency for initial coupling studies. On the other hand, a linear elastic model was identified as an optimal starting point for both the subchondral bone plate and the subchondral trabecular bone, reflecting their dense and stiff nature, and providing a coherent framework for early-stage multilayer integration. This layered modeling approach enables the development of physiologically coherent and computationally efficient representations of osteochondral region modeling. Furthermore, by establishing a layer-specific modeling approach, this review paves the way for modular in silico simulations through the coupling of computational models. Such an integrative framework supports scaffold design, in vitro experimentation, preclinical validation, and the mechanobiological exploration of osteochondral degeneration and repair. These efforts are essential for deepening our understanding of tissue responses under both physiological and pathological conditions. Ultimately, this work provides a robust theoretical foundation for future in silico and in vitro studies aimed at advancing osteochondral tissue regeneration strategies.

骨软骨组织的综合生物力学模型:多层次视角。
了解骨软骨组织的复杂力学行为对于改进实验模型和推进关节健康和退变的研究至关重要。本综述全面分析了目前用于表征骨软骨区域不同层的本构模型,从关节软骨到软骨下骨,包括潮汐标记和钙化软骨层等中间区域。每一层都具有独特的结构和力学性能,因此需要一种特定于层的建模方法。通过对现有数学模型的严格比较,粘弹性模型被建议作为建模关节软骨区、潮标和钙化软骨层的实用起点,因为它捕获了基本的时间依赖性行为,如蠕变和应力松弛,同时确保了初始耦合研究的计算效率。另一方面,线弹性模型被认为是软骨下骨板和软骨下骨小梁的最佳起点,反映了它们的致密和刚性性质,并为早期多层整合提供了一个连贯的框架。这种分层建模方法使骨软骨区域建模的生理连贯和计算高效表示的发展成为可能。此外,通过建立特定于层的建模方法,本综述通过计算模型的耦合为模块化硅模拟铺平了道路。这种综合框架支持支架设计、体外实验、临床前验证以及骨软骨变性和修复的机械生物学探索。这些努力对于加深我们对生理和病理条件下组织反应的理解是必不可少的。最终,这项工作为未来旨在推进骨软骨组织再生策略的硅和体外研究提供了坚实的理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioengineering
Bioengineering Chemical Engineering-Bioengineering
CiteScore
4.00
自引率
8.70%
发文量
661
期刊介绍: Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering
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