Leukocyte-Rich Platelet-Rich Plasma's Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials.

IF 3.8 3区医学 Q2 ENGINEERING, BIOMEDICAL

Bioengineering Pub Date : 2025-06-05 DOI:10.3390/bioengineering12060617

Peiyuan Tang, Meihui Huang, Wenfeng Xiao, Ting Wen, Pavel Volotovsky, Mikhail Gerasimenko, Shiyao Chu, Shuguang Liu, Kai Zhang, Yusheng Li

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引用次数: 0

Abstract

Background: Arthroscopic rotator cuff repair faces high retear risks in multi-tendon injuries due to insufficient biological healing; leukocyte-rich PRP may enhance tendon-bone integration through inflammatory modulation and growth factor release. Methods: Four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched until March 2025. Literature screening, quality evaluation, and data extraction were performed according to inclusion and exclusion criteria. GRADE was used to grade the strength of the evidence and the results. Results: The main finding of this study was that leukocyte-rich platelet-rich plasma combined with arthroscopic surgery for rotator cuff injuries can improve the Constant Score (MD = 1.13, 95% CI: 0.19, 2.07, p = 0.02, I² = 47%), American Shoulder and Elbow Surgeons score (MD = 6.02, 95% CI: 4.67, 7.36, p < 0.01, I² = 0%), and University of California, Los Angeles score (MD = 1.20, 95% CI: 0.34, 2.06, p < 0.01, I² = 0%) of patients with rotator cuff tear after treatment, and reduce the postoperative Visual Analog Scale score (MD = -0.62, 95% CI: -1.16, -0.08, p = 0.02, I² = 83%) of patients. However, there were no statistical differences regarding the Simple Shoulder Test (MD = 0.08, 95% CI: -0.23, 0.39, p = 0.61, I² = 5%). Conclusions: Based on current evidence, the use of LR-PRP in arthroscopic rotator cuff repair could lessen postoperative pain and improve postoperative functional scores in individuals with rotator cuff injuries.

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富白细胞富血小板血浆在关节镜下肩袖修复中的临床疗效：一项随机对照试验的meta分析。

背景：关节镜下肩袖修复术由于生物愈合不足，多肌腱损伤存在较高的复发风险；富含白细胞的PRP可能通过炎症调节和生长因子释放促进肌腱-骨整合。方法：截至2025年3月检索PubMed、Embase、Cochrane Library、Web of Science 4个数据库。根据纳入和排除标准进行文献筛选、质量评价和资料提取。GRADE用于对证据和结果的强度进行分级。结果：本研究的主要发现是富白细胞富血小板血浆联合关节镜手术治疗肩cuff损伤可提高Constant评分（MD = 1.13, 95% CI: 0.19, 2.07, p = 0.02, I2 = 47%）、American Shoulder and肘部外科医生评分（MD = 6.02, 95% CI: 4.67, 7.36, p < 0.01, I2 = 0%）和加州大学洛杉矶分校评分(MD = 1.20, 95% CI：0.34, 2.06, p < 0.01, I2 = 0%)，降低术后患者视觉模拟量表评分（MD = -0.62, 95% CI: -1.16, -0.08, p = 0.02, I2 = 83%）。然而，简单肩部试验无统计学差异（MD = 0.08, 95% CI: -0.23, 0.39, p = 0.61, I2 = 5%）。结论：根据目前的证据，在关节镜下肩袖修复中使用LR-PRP可以减轻术后疼痛并提高肩袖损伤患者的术后功能评分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioengineering Chemical Engineering-Bioengineering

CiteScore

4.00

自引率

8.70%

发文量

661

期刊介绍： Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering