Impact and management of warm autoimmune haemolytic anaemia associated with systemic lupus erythematosus

IF 8.3 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-06-23 DOI:10.1016/j.autrev.2025.103858

Guillermo J. Pons-Estel , Marta Mosca , Daniel J. Wallace , Federico Zazzetti , Ann Leon , Wim Noël , Andreia Pierce , Tarek Ebrahim , Irina Murakhovskaya

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引用次数: 0

Abstract

Warm autoimmune haemolytic anaemia (wAIHA) is a rare autoantibody-mediated disorder that may occur in association with systemic lupus erythematosus (SLE). The clinical course of wAIHA is highly variable, ranging from anaemia compensated adequately by reticulocytosis to severe, life-threatening cases. While insights into the pathogenesis of wAIHA in SLE remain limited, emerging evidence highlights the risk factors and impact of wAIHA in the context of SLE. Management of wAIHA associated with SLE remains challenging as there is limited clinical evidence to support treatment decisions. New therapies, some that target underlying disease mechanisms relevant to both conditions, are in development. In this review, we examine the impact of wAIHA on clinical outcomes for patients with SLE, summarise the current management strategies along with unmet needs, and provide an update on novel therapeutic strategies.

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与系统性红斑狼疮相关的温热自身免疫性溶血性贫血的影响和管理。

温热自身免疫性溶血性贫血（wAIHA）是一种罕见的自身抗体介导的疾病，可能与系统性红斑狼疮（SLE）相关。wAIHA的临床病程变化很大，从网状细胞缺乏症充分补偿的贫血到严重的危及生命的病例。虽然对wAIHA在SLE中的发病机制的了解仍然有限，但新出现的证据强调了wAIHA在SLE背景下的危险因素和影响。由于支持治疗决策的临床证据有限，与SLE相关的wAIHA的管理仍然具有挑战性。一些针对与这两种疾病相关的潜在疾病机制的新疗法正在开发中。在这篇综述中，我们研究了wAIHA对SLE患者临床结果的影响，总结了当前的管理策略以及未满足的需求，并提供了新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.