Antisense oligonucleotides as drugs with both direct and indirect antiviral actions

IF 4.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Antiviral research Pub Date : 2025-06-23 DOI:10.1016/j.antiviral.2025.106219

Jin Hong, Vivek K. Rajwanshi

引用次数: 0

Abstract

In this review, we provide a historical and current guide of recent advances in the development of ASOs either targeting viruses directly, or indirectly through modulation of host factors. Although preclinical and discovery assets are mentioned in this review, more extensive coverage is given to clinical stage assets. Most of these clinical assets are currently concentrated in the fight to eradicate hepatitis B virus (HBV), and hepatitis C virus (HCV). Progresses have also been made in extrahepatic delivery of oligonucleotides and the possibility of treating respiratory virus infections in lungs with ASOs would be feasible.

查看原文本刊更多论文

反义寡核苷酸作为具有直接和间接抗病毒作用的药物。

在这篇综述中，我们提供了历史和当前的最新进展指南，无论是直接靶向病毒，还是通过调节宿主因子间接靶向病毒。虽然本综述中提到了临床前资产和发现资产，但更广泛的报道是给予临床阶段资产。目前，这些临床资产大多集中在根除乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的斗争中。在肝外递送寡核苷酸方面也取得了进展，用ASOs治疗肺部呼吸道病毒感染的可能性将是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Antiviral research 医学-病毒学

CiteScore

17.10

自引率

3.90%

发文量

157

审稿时长

34 days

期刊介绍： Antiviral Research is a journal that focuses on various aspects of controlling viral infections in both humans and animals. It is a platform for publishing research reports, short communications, review articles, and commentaries. The journal covers a wide range of topics including antiviral drugs, antibodies, and host-response modifiers. These topics encompass their synthesis, in vitro and in vivo testing, as well as mechanisms of action. Additionally, the journal also publishes studies on the development of new or improved vaccines against viral infections in humans. It delves into assessing the safety of drugs and vaccines, tracking the evolution of drug or vaccine-resistant viruses, and developing effective countermeasures. Another area of interest includes the identification and validation of new drug targets. The journal further explores laboratory animal models of viral diseases, investigates the pathogenesis of viral diseases, and examines the mechanisms by which viruses avoid host immune responses.