Diagnostic Approach and Pathological Characterization of Metastatic Intrahepatic Cholangiocarcinoma in a Captive Puma (Puma concolor).

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-06-19 DOI:10.3390/ani15121821

Elisa Mazzotta, Claudia Zanardello, Giovanni De Zottis, Antonio Barberio, Mery Campalto, Federico Martignago, Giulia Maria De Benedictis, Carlo Guglielmini, Francesca Zanusso, Greta Foiani

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Abstract

A 16-year-old captive male puma (Puma concolor) presented with progressive weight loss and acute mild gastrointestinal symptoms. Clinical examination, and diagnostic imaging revealed abdominal, pleural, and pericardial effusion and nodular masses in multiple organs. Due to the clinical condition, multiple organ involvement, and a poor prognosis, compassionate euthanasia was chosen. Necropsy revealed abundant cavitary effusions and multiple yellow-white neoplastic masses involving the left hepatic lobes. Metastatic nodules were observed throughout the peritoneum, pericardium, kidney, spleen, and spermatic cord. Histologically, the tumor was characterized by tubular and acinar structures embedded in a desmoplastic stroma. Neoplastic cells were positive for pan-cytokeratins (CKs), CK7, and, to a lesser extent, CK20. The gross, histologic, and immunohistochemical findings were consistent with intrahepatic metastatic cholangiocarcinoma.

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圈养美洲狮（美洲狮）转移性肝内胆管癌的诊断方法和病理特征。

一只16岁的圈养雄性美洲狮（美洲狮）表现为进行性体重减轻和急性轻度胃肠道症状。临床检查及诊断影像显示腹部、胸膜及心包积液及多器官结节性肿块。由于临床情况，多器官受累，预后不佳，选择了同情安乐死。尸检显示左侧肝叶有大量腔内积液及多个黄白色肿瘤肿块。转移结节遍及腹膜、心包、肾脏、脾脏和精索。组织学上，肿瘤的特点是管状和腺泡结构嵌在间质间。肿瘤细胞泛细胞角蛋白（pan-cytokeratins, CKs）、CK7阳性，CK20阳性程度较轻。大体、组织学和免疫组化结果与肝内转移性胆管癌一致。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).