Vaginal microbiome composition in women with HIV undergoing treatment of cervical transformation zone in a screen and treat program in Zambia.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-07-15 Epub Date: 2025-06-26 DOI:10.1097/QAD.0000000000004187

Leeya F Pinder, Pierre Bertrand, Veronica Fertitta, Vincent Cahais, Mulindi Mwanahamuntu, Namakau Nyambe, Samson Chisele, Aaron Lunda Shibemba, Sandrine McKay-Chopin, Cyrille Cuenin, Eric Lucas, Michael Korenjak, Richard Muwonge, Akram Ghantous, Zdenko Herceg, Groesbeck P Parham, Jiri Zavadil, Partha Basu, Tarik Gheit

引用次数: 0

Abstract

This study assessed the vaginal microbiome in women with HIV undergoing cervical transformation zone treatment in Zambia. 16S rRNA sequencing showed lower microbial diversity in successful outcomes (N = 18) than those with treatment failure (N = 17) treatment outcome, with Lactobacillus abundance correlated with success. Moreover, HPV-negative women (N = 12) had higher Lactobacillus levels and less pathogens than HPV-positive women (N = 12). These findings suggest a Lactobacillus-dominated microbiome may be associated with positive treatment outcomes.

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阴道微生物组组成的妇女艾滋病毒接受治疗宫颈转化区在筛查和治疗方案在赞比亚。

这项研究评估了赞比亚接受宫颈转化区治疗的艾滋病毒感染者阴道微生物组，16S rRNA测序显示，成功结果（N = 18）的微生物多样性低于治疗失败结果（N = 17），乳酸杆菌丰度与治疗成功相关。此外，hpv阴性女性（N = 12）的乳酸菌水平高于hpv阳性女性（N = 12），病原体较少。这些发现表明，以乳酸杆菌为主的微生物群可能与积极的治疗结果有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.