{"title":"The role of SPP1<sup>+</sup>TAMs in cancer: Impact on patient prognosis and future therapeutic targets.","authors":"Xiang Li, Jie Lian, Haibo Lu","doi":"10.1002/ijc.70018","DOIUrl":null,"url":null,"abstract":"<p><p>Tumor-associated macrophages (TAMs) are a critical population of immune cells that infiltrate the tumor microenvironment (TME) and significantly influence cancer progression, prognosis, and treatment. SPP1<sup>+</sup>TAMs represent a tumor-promoting subset of TAMs characterized by their ability to secrete osteopontin, along with various cytokines and chemokines, and to interact with a diverse array of ligands. Within the tumor microenvironment, SPP1<sup>+</sup>TAMs are primarily localized to hypoxic and necrotic regions, as well as along the tumor margins. Studies have shown that SPP1<sup>+</sup>TAMs promote tumor angiogenesis, invasion, metastasis, and immunosuppression. The infiltration of SPP1<sup>+</sup>TAMs has been associated with poor prognosis in cancer patients. Furthermore, their presence may influence disease progression and treatment response. Targeting SPP1<sup>+</sup>TAMs has the potential to reduce immunosuppression and augment immunotherapeutic efficacy, thereby contributing to improved treatment outcomes.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ijc.70018","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Tumor-associated macrophages (TAMs) are a critical population of immune cells that infiltrate the tumor microenvironment (TME) and significantly influence cancer progression, prognosis, and treatment. SPP1+TAMs represent a tumor-promoting subset of TAMs characterized by their ability to secrete osteopontin, along with various cytokines and chemokines, and to interact with a diverse array of ligands. Within the tumor microenvironment, SPP1+TAMs are primarily localized to hypoxic and necrotic regions, as well as along the tumor margins. Studies have shown that SPP1+TAMs promote tumor angiogenesis, invasion, metastasis, and immunosuppression. The infiltration of SPP1+TAMs has been associated with poor prognosis in cancer patients. Furthermore, their presence may influence disease progression and treatment response. Targeting SPP1+TAMs has the potential to reduce immunosuppression and augment immunotherapeutic efficacy, thereby contributing to improved treatment outcomes.
期刊介绍:
The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories:
-Cancer Epidemiology-
Cancer Genetics and Epigenetics-
Infectious Causes of Cancer-
Innovative Tools and Methods-
Molecular Cancer Biology-
Tumor Immunology and Microenvironment-
Tumor Markers and Signatures-
Cancer Therapy and Prevention