The role of SPP1+TAMs in cancer: Impact on patient prognosis and future therapeutic targets.

IF 5.7 2区 医学 Q1 ONCOLOGY
Xiang Li, Jie Lian, Haibo Lu
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引用次数: 0

Abstract

Tumor-associated macrophages (TAMs) are a critical population of immune cells that infiltrate the tumor microenvironment (TME) and significantly influence cancer progression, prognosis, and treatment. SPP1+TAMs represent a tumor-promoting subset of TAMs characterized by their ability to secrete osteopontin, along with various cytokines and chemokines, and to interact with a diverse array of ligands. Within the tumor microenvironment, SPP1+TAMs are primarily localized to hypoxic and necrotic regions, as well as along the tumor margins. Studies have shown that SPP1+TAMs promote tumor angiogenesis, invasion, metastasis, and immunosuppression. The infiltration of SPP1+TAMs has been associated with poor prognosis in cancer patients. Furthermore, their presence may influence disease progression and treatment response. Targeting SPP1+TAMs has the potential to reduce immunosuppression and augment immunotherapeutic efficacy, thereby contributing to improved treatment outcomes.

SPP1+ tam在癌症中的作用:对患者预后和未来治疗靶点的影响
肿瘤相关巨噬细胞(tumor associated macrophages, tam)是浸润肿瘤微环境(tumor microenvironment, TME)并显著影响肿瘤进展、预后和治疗的重要免疫细胞群。SPP1+ tam代表了tam的肿瘤促进亚群,其特征是它们能够分泌骨桥蛋白,以及各种细胞因子和趋化因子,并与多种配体相互作用。在肿瘤微环境中,SPP1+ tam主要定位于缺氧和坏死区域,以及沿肿瘤边缘。研究表明SPP1+ tam促进肿瘤血管生成、侵袭、转移和免疫抑制。SPP1+ tam的浸润与癌症患者预后不良有关。此外,它们的存在可能影响疾病进展和治疗反应。靶向SPP1+ tam具有减少免疫抑制和增强免疫治疗效果的潜力,从而有助于改善治疗结果。
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来源期刊
CiteScore
13.40
自引率
3.10%
发文量
460
审稿时长
2 months
期刊介绍: The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories: -Cancer Epidemiology- Cancer Genetics and Epigenetics- Infectious Causes of Cancer- Innovative Tools and Methods- Molecular Cancer Biology- Tumor Immunology and Microenvironment- Tumor Markers and Signatures- Cancer Therapy and Prevention
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