Rectal Neuroendocrine Tumor With Non-Atypical Mucous Cell Glands: A Case Report

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY
JGH Open Pub Date : 2025-06-26 DOI:10.1002/jgh3.70208
Akira Ishikawa, Hidenori Tanaka, Ken Yamashita, Shiro Oka, Shinji Mii
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Abstract

Introduction

Neuroendocrine neoplasms (NENs) of rectal origin containing non-neuroendocrine components are extremely rare. Additionally, there have been no previous reports of NENs accompanied by nonmalignant components. Herein, we report a case of an NEN accompanied by mucous cell glands that could not be regarded as a carcinoma.

Case Presentation

A Japanese woman in her 30s underwent a colonoscopy that revealed a yellowish submucosal tumor-like protrusion in the rectum. Endoscopic findings suggested a high possibility of NEN; therefore, endoscopic mucosal resection was performed. Histopathologically, it was found that tumor cells had invaded beyond the muscularis mucosa into the submucosa. The tumor predominantly consisted of neuroendocrine tumor (NET) components with mucous cell glands observed in 5% of the tumor. The mucous cell glands were Periodic acid-Schiff-positive and immunohistochemically positive for CK20, whereas synaptophysin, CD56, and chromogranin A were negative. Based on the above findings, the pathological diagnosis was NET G1 with mucous cell glands.

Conclusion

This is the first reported case worldwide. Further discussion is needed to address the atypical nature of the glandular component and explore the differences and similarities with entities such as mixed neuroendocrine–non-NENs.

Abstract Image

直肠神经内分泌肿瘤伴非典型黏液细胞腺1例报告
神经内分泌肿瘤(NENs)的直肠起源包含非神经内分泌成分是非常罕见的。此外,以前没有NENs伴非恶性成分的报道。在此,我们报告一个病例的NEN伴有黏液细胞腺不能被视为癌。病例介绍一名30多岁的日本妇女在结肠镜检查中发现直肠黏膜下有黄色肿瘤样突出物。内镜检查提示NEN的可能性高;因此,行内镜下粘膜切除术。组织病理学检查发现肿瘤细胞已越过粘膜肌层侵入粘膜下层。肿瘤主要由神经内分泌肿瘤(NET)组成,5%的肿瘤可见黏液细胞腺。粘膜细胞腺呈周期性酸希夫阳性,CK20免疫组化阳性,而突触素、CD56和嗜铬粒蛋白A呈阴性。基于以上结果,病理诊断为NET G1伴黏液细胞腺。结论:这是全球首例报告病例。需要进一步的讨论来解决腺体成分的非典型性质,并探索与混合神经内分泌-非nens等实体的异同。
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来源期刊
JGH Open
JGH Open GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
143
审稿时长
7 weeks
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