Longitudinal Assessment of QT Apex in Tumor-Bearing Dogs Receiving Doxorubicin Monotherapy

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-06-26 DOI:10.1111/jvim.70169

Keita Kitagawa, Jacob Ryave, Robert A. Sanders, Ji-Hyun Lee, Zhongyue Zhang, Paulo Vilar Saavedra

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Abstract

Background

The cardiac morphologic and functional derangements induced by doxorubicin (DOX) are referred to as DOX-induced cardiotoxicity (DOX-IC). Prolongation of the QT apex (QTa) has been identified as a potential marker for the early detection of DOX-IC in humans.

Objectives

Describe changes in QTa that occur in dogs with cancer undergoing DOX monotherapy.

Animals

Forty-five client-owned dogs.

Methods

Descriptive analysis of data routinely recorded as part of case management of dogs with cancer. Dogs included in the study had a confirmed malignant neoplasm, received DOX as a monotherapy, and had at least 4 ECGs > 30 s. All ECGs included in the study were recorded before DOX administration. Five heartbeats with a stable signal and minimal artifact were randomly selected from each dog, and the QTa was blindly evaluated in lead II, lead III, or both. Subsequently, a linear mixed model was used to quantify the effect of a cumulative dose of DOX on the QTa interval, adjusting for the effect of the other clinical variables.

Results

Forty-five dogs met the inclusion criteria. Among them, 39/45 received five DOX treatments and 26/45 received six DOX treatments. For ECG analysis, 234 ECGs were evaluated for changes in the QTa. The average cumulative dose of DOX was 154.1 mg/m². There was no significant impact of the DOX treatments on the change in QTa (p = 0.8).

Conclusions

Administration of DOX up to a cumulative dose of 154.1 mg/m² does not result in QTa prolongation.

Abstract Image

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接受阿霉素单药治疗的荷瘤犬QT顶点的纵向评价

多柔比星（DOX）引起的心脏形态和功能紊乱被称为DOX诱导的心脏毒性（DOX- ic）。QT顶点延长（QTa）已被确定为人类早期检测DOX-IC的潜在标志物。目的描述在接受DOX单药治疗的癌症犬中QTa的变化。45只客户拥有的狗。方法对犬癌病例管理中常规记录的数据进行描述性分析。纳入研究的犬均确诊为恶性肿瘤，接受DOX单药治疗，且至少有4次心电图[gt； 30]。所有纳入研究的心电图均在给药前记录。从每只狗中随机选择5次信号稳定且干扰最小的心跳，并在导联II、导联III或两者中盲目评估QTa。随后，使用线性混合模型来量化DOX累积剂量对QTa间隔的影响，并调整其他临床变量的影响。结果45只狗符合纳入标准。其中39/45例接受5次DOX治疗，26/45例接受6次DOX治疗。在心电图分析中，对234例心电图进行QTa变化评估。DOX平均累积剂量为154.1 mg/m2。DOX治疗对QTa变化无显著影响（p = 0.8）。结论：累积剂量为154.1 mg/m2的DOX不会导致QTa延长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.