Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-06-20 DOI:10.1016/j.cegh.2025.102102

Betcy George , Porkodi Arjunan , Abraham M. Ittyachen , M. Rajkumar , N.A. Sheela Shenai , Soney Meleth Varghese , Ramesh Chandrababu

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引用次数: 0

Abstract

Background

Research evidence highlights modifiable risk factors as key elements in preventing hypertension and its complications. This study explores their association with hypertension to inform preventive strategies.

Objectives

We assessed the socio-clinical, bio-physiological, and biochemical parameters and its associated factors.

Materials and methods

This hospital-based cross-sectional study involved 220 hypertensive patients. The outcome variables were assessed using biophysiological and biochemical methods.

Association between socio-clinical variables with bio-physiological and biochemical parameters was done with the Mann-Whitney U test, ANOVA, Kruskal-Wallis ANOVA, and Spearman's correlation. p < 0.05 was considered statistically significant.

Results

71.36 % had hypertension for the past 10 years, 73.63 % were on anti-hypertensives for 10 years, and 80.91 % were prescribed a single drug. The median HDL and LDL levels were 58 mg/dL and 140 mg/dL, respectively.

Weight emerged as a strong positive contributor to all three BP measures [systolic blood pressure (SBP): p = 0.026, diastolic blood pressure (DBP): p = 0.001, and mean arterial pressure (MAP): p = 0.001], highlighting its potential role in BP control. Gender disparities were evident, with men having higher DBP (p < 0.001) and MAP (p = 0.003) compared to women. Smoking habit was particularly detrimental, showing a significant association with higher DBP (p = 0.016). A link between heart rate and comorbid conditions (p = 0.044) suggests a potential interplay between weight, hypertension, and overall health. Linear regression analysis revealed a statistically significant positive association between weight, DBP, and MAP (p < 0.05 for both).

Conclusions

Age showed a weak correlation, and weight management emerged as a crucial factor for BP control. Strategies to decrease weight would be crucial for the control of hypertension.

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高血压患者的生物生理生化参数-横断面研究

研究证据强调可改变的危险因素是预防高血压及其并发症的关键因素。本研究探讨了它们与高血压的关系，为预防策略提供信息。目的评估社会临床、生物生理、生化指标及其相关因素。材料与方法以医院为基础的横断面研究纳入220例高血压患者。结果变量采用生物生理学和生化方法进行评估。社会临床变量与生物生理生化参数之间的关系采用Mann-Whitney U检验、方差分析、Kruskal-Wallis方差分析和Spearman相关。p <； 0.05认为有统计学意义。结果71.36% %的患者过去10年有高血压病史，73.63% %的患者10年在服用降压药，80.91 %的患者使用单一药物。中位HDL和LDL水平分别为58 mg/dL和140 mg/dL。体重在所有三项血压测量中都是一个强有力的积极因素[收缩压（SBP）： p = 0.026，舒张压（DBP）： p = 0.001，平均动脉压（MAP）： p = 0.001]，突出了它在血压控制中的潜在作用。性别差异明显，与女性相比，男性的DBP （p <； 0.001）和MAP （p = 0.003）更高。吸烟习惯尤其有害，显示出与高DBP显著相关（p = 0.016）。心率与合并症之间的联系（p = 0.044）表明体重、高血压和整体健康之间存在潜在的相互作用。线性回归分析显示，体重、DBP和MAP之间存在统计学上显著的正相关（p <； 0.05）。结论sage与血压的相关性较弱，体重管理是控制血压的关键因素。减肥策略对于控制高血压至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.