Rose bengal photodynamic antimicrobial therapy combined with amniotic membrane graft for the management of infectious keratitis in a patient with keratoprosthesis

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-06-16 DOI:10.1016/j.ajoc.2025.102365

Ruth Eskenazi-Betech, Guillermo Raul Vera-Duarte, Ana P. Murillo-López, Aldo Hernandez-Hernandez, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O. Graue-Hernandez

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引用次数: 0

Abstract

Purpose

To describe the use of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) combined with amniotic membrane graft (AMG) as a novel surgical technique for infectious keratitis in a patient with Boston Keratoprosthesis (B-Kpro) type 1 Lucia.

Methods

A 91-year-old woman with a history of B-Kpro type 1 Lucia implantation in both eyes presented for routine follow-up complaining of pain and redness in the left eye. Slit-lamp examination revealed a 6 mm corneal infiltrate with an epithelial defect adjacent to the optic stem. After 2 weeks of topical antimicrobial therapy without any improvement, the decision was made to perform RB-PDAT in conjunction with an AMG. The infectious keratitis resolved within 21 days.

Conclusions

The combination of RB-PDAT and AMG may be considered as a surgical alternative in patients with keratoprosthesis complicated by severe infectious keratitis refractory to standard medical treatment.

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玫瑰孟加拉光动力抗菌素治疗联合羊膜移植治疗一例角膜假体患者的感染性角膜炎

目的探讨玫瑰孟加拉光动力抗菌素治疗（RB-PDAT）联合羊膜移植（AMG）作为治疗1型Lucia波士顿角膜假体（B-Kpro）患者感染性角膜炎的新手术技术。方法91岁女性，双眼B-Kpro 1型Lucia植入术，以左眼疼痛、红肿为主诉接受常规随访。裂隙灯检查显示6毫米角膜浸润伴视神经干附近上皮缺损。经过2周的局部抗菌治疗，没有任何改善，决定进行RB-PDAT联合AMG。感染性角膜炎在21天内痊愈。结论RB-PDAT联合AMG可作为标准药物治疗难治性严重感染性角膜炎合并角膜移植的一种手术选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.