The role and importance of rare earth elements as dopants for hydroxyapatite structure: a comprehensive review

IF 3.9 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Science and Engineering: B Pub Date : 2025-06-27 DOI:10.1016/j.mseb.2025.118545

Rebaz Obaid Kareem , Bahroz Kareem Mahmood , Azeez A. Barzinjy , Niyazi Bulut , Omer Kaygili , Serhat Keser , Tankut Ates

{"title":"The role and importance of rare earth elements as dopants for hydroxyapatite structure: a comprehensive review","authors":"Rebaz Obaid Kareem , Bahroz Kareem Mahmood , Azeez A. Barzinjy , Niyazi Bulut , Omer Kaygili , Serhat Keser , Tankut Ates","doi":"10.1016/j.mseb.2025.118545","DOIUrl":null,"url":null,"abstract":"<div><div>This comprehensive review delves into the significance of rare earth elements (REEs) as dopants in hydroxyapatite (HAp) structures, highlighting their role in modulating the material’s crystallinity, solubility, and bioactivity. The unique properties of REEs, such as their ability to form ionic bonds with hydroxyapatite, are discussed in relation to their impact on the material’s interactions with biological molecules. The review also examines the effects of REE doping on the <em>in vitro</em> and <em>in vivo</em> behavior of HAp, including its influence on cell proliferation, differentiation, and mineralization. Furthermore, the potential applications of REE-doped HAp in orthopedic and dental implants, as well as its potential in bone tissue engineering, are explored. This review provides a thorough understanding of the role and importance of REEs as dopants in HAp structures, shedding light on their potential to revolutionize the development of biomaterials for biomedical applications, especially in bone tissues engineering.</div></div>","PeriodicalId":18233,"journal":{"name":"Materials Science and Engineering: B","volume":"321 ","pages":"Article 118545"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Science and Engineering: B","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0921510725005690","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

This comprehensive review delves into the significance of rare earth elements (REEs) as dopants in hydroxyapatite (HAp) structures, highlighting their role in modulating the material’s crystallinity, solubility, and bioactivity. The unique properties of REEs, such as their ability to form ionic bonds with hydroxyapatite, are discussed in relation to their impact on the material’s interactions with biological molecules. The review also examines the effects of REE doping on the in vitro and in vivo behavior of HAp, including its influence on cell proliferation, differentiation, and mineralization. Furthermore, the potential applications of REE-doped HAp in orthopedic and dental implants, as well as its potential in bone tissue engineering, are explored. This review provides a thorough understanding of the role and importance of REEs as dopants in HAp structures, shedding light on their potential to revolutionize the development of biomaterials for biomedical applications, especially in bone tissues engineering.

Abstract Image

查看原文本刊更多论文

稀土元素作为羟基磷灰石结构掺杂剂的作用和重要性综述

本文综述了稀土元素（ree）作为羟基磷灰石（HAp）结构的掺杂剂的重要性，强调了它们在调节材料的结晶度、溶解度和生物活性方面的作用。稀土元素的独特性质，如它们与羟基磷灰石形成离子键的能力，讨论了它们对材料与生物分子相互作用的影响。本文还研究了稀土掺杂对羟基磷灰石体内和体外行为的影响，包括其对细胞增殖、分化和矿化的影响。此外，还探讨了稀土掺杂HAp在骨科和牙科种植体中的潜在应用，以及在骨组织工程中的潜力。本文综述了稀土元素在羟基磷灰石结构中作为掺杂剂的作用和重要性，揭示了稀土元素在生物医学应用，特别是骨组织工程中生物材料的革命性发展潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Materials Science and Engineering: B 工程技术-材料科学：综合

CiteScore

5.60

自引率

2.80%

发文量

481

审稿时长

3.5 months

期刊介绍： The journal provides an international medium for the publication of theoretical and experimental studies and reviews related to the electronic, electrochemical, ionic, magnetic, optical, and biosensing properties of solid state materials in bulk, thin film and particulate forms. Papers dealing with synthesis, processing, characterization, structure, physical properties and computational aspects of nano-crystalline, crystalline, amorphous and glassy forms of ceramics, semiconductors, layered insertion compounds, low-dimensional compounds and systems, fast-ion conductors, polymers and dielectrics are viewed as suitable for publication. Articles focused on nano-structured aspects of these advanced solid-state materials will also be considered suitable.