One Wnt to lead them all: a Wnt1 primer

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2025-06-24 DOI:10.1016/j.diff.2025.100884

Arne C. Lekven, Sarah Empie , Richard Saoud

引用次数: 0

Abstract

Wnt1 was originally identified by virtue of its mutant phenotype in Drosophila and its causation of mammary tumors in mice, but, in its history, Wnt1 has been a nexus for ground-breaking discoveries in developmental biology, evolutionary biology, and disease. Wnt1 orthologs are found across the animal kingdom and play a role in a multitude of developmental and homeostatic mechanisms involving proliferation, cell fate specification, stem cell maintenance and tissue homeostasis. In vertebrates, Wnt1 is located in a syntenic chromosome neighborhood that is essential to its conserved expression in the developing nervous system. Wnt1 is essential for nervous system development, in particular for the midbrain and anterior hindbrain. Wnt1 also is essential for bone homeostasis, and mutant alleles are behind severe cases of recessive osteogenesis imperfecta in humans. This primer reviews the illustrious history of Wnt1, its gene structure and regulation, expression, loss-of-function consequences, and connection to human disease.

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一个Wnt可以引领所有Wnt：一个Wnt1引物

Wnt1最初是由于其在果蝇中的突变表型和在小鼠中引起乳腺肿瘤而被发现的，但是，在其历史上，Wnt1已经成为发育生物学、进化生物学和疾病领域突破性发现的纽带。Wnt1同源基因在动物王国中广泛存在，并在多种发育和体内平衡机制中发挥作用，包括增殖、细胞命运规范、干细胞维持和组织体内平衡。在脊椎动物中，Wnt1位于同染色体附近，这对其在发育中的神经系统中的保守表达至关重要。Wnt1对神经系统发育至关重要，特别是中脑和后脑前部。Wnt1也是骨稳态所必需的，突变等位基因是人类严重隐性成骨不全病例的原因。本引物回顾了Wnt1的辉煌历史、其基因结构和调控、表达、功能丧失后果以及与人类疾病的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.