Impact of Antidepressants on Dental Implant Osseointegration: A Comparative Evaluation of Nanohydroxyapatite and Double Acid-Etching Surface Treatments.

Nilson Matias Pereira Júnior, Daniel Nunes de Oliveira, Pedro Giorgetti Montagner, Lucas Novaes Teixeira, Juliana Cama Ramacciato, Elizabeth Ferreira Martinez
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Abstract

Purpose: Depression is a neurobiological disorder responsive to treatment with antidepressants. Some investigative research has indicated a negative correlation between the use of these drugs and failure of dental implant osseointegration. This study aimed to make an in vivo assessment of the impact of two antidepressants with distinct mechanisms of action on the osseointegration of dental implants, and their correlation with two different surface treatments.

Materials and methods: A total of 15 Rattus norvegicus albinus specimens received 4 titanium implants, 2 exhibiting a double acid-etched (DEA) surface, and 2 exhibiting a DEA surface coated in plasma-sprayed nanohydroxyapatite (NANO), distributed to the right and left tibias. The rats were randomly assigned to three groups: sertraline, amitriptyline, or saline, and received a daily oral dose of 5mg/kg, 5mg/kg, or 0.1ml, respectively, for 14 days prior to surgery, and for an additional 21 days thereafter until euthanasia. Removal torque (RT), bone-implant contact (BIC), and bone area (BA) were evaluated.

Results: The findings indicated that both the removal torque and the BA percentage decreased in the groups administered antidepressants. The BIC percentage was similar among the groups when the NANO surface implant was used.

Conclusions: It can be concluded that the antidepressants studied were associated with a higher possibility of osseointegration failure. Implants featuring NANO surface treatment could be used as an alternative in these instances to mitigate the negative impact of antidepressant therapy on bone repair.

抗抑郁药对种植体骨整合的影响:纳米羟基磷灰石和双酸蚀表面处理的比较评价。
目的:抑郁症是一种对抗抑郁药物治疗有反应的神经生物学障碍。一些调查研究表明,这些药物的使用与种植体骨整合失败之间存在负相关。本研究旨在对两种具有不同作用机制的抗抑郁药对种植体骨整合的影响及其与两种不同表面处理的相关性进行体内评估。材料与方法:15只褐家鼠标本共植入4枚钛植入物,其中2枚为双酸蚀(DEA)表面,2枚为等离子喷涂纳米羟基磷灰石(NANO)涂层的DEA表面,分布于左右胫骨。将大鼠随机分为舍曲林、阿米替林和生理盐水三组,术前14天每天口服5mg/kg、5mg/kg或0.1ml,术后21天口服,直至安乐死。评估去除扭矩(RT)、骨-种植体接触(BIC)和骨面积(BA)。结果:研究结果表明,服用抗抑郁药组的去除扭矩和BA百分比均有所下降。使用纳米表面种植体时,各组间BIC百分比相似。结论:所研究的抗抑郁药物与骨整合失败的可能性较高有关。在这些情况下,纳米表面处理的植入物可以作为一种替代方法,以减轻抗抑郁治疗对骨修复的负面影响。
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