Investigation of A2 allele frequency in Taiwanese Holstein cattle using genetic testing.

IF 1
C H Chao, J W Shiau
{"title":"Investigation of A2 allele frequency in Taiwanese Holstein cattle using genetic testing.","authors":"C H Chao, J W Shiau","doi":"10.24425/pjvs.2025.154951","DOIUrl":null,"url":null,"abstract":"<p><p>β-Casein accounts for approximately 30% of total milk protein, with the A1 and A2 variants being the most common. A1 β-casein may release β-casomorphin-7 (BCM-7) during digestion, which is associated with adverse health effects, whereas A2 β-casein does not. This study investigated the A2 allele frequency and its potential influence on milk performance in Holstein cattle in Taiwan. A total of 1,050 cows from five herds were genotyped using the GeneSeek 50K SNP chip. The A2 allele frequency ranged from 0.58 to 0.75 among herds, with an average of 0.66. Hardy-Weinberg equilibrium tests indicated no significant deviation within herds. Pedigree validation confirmed Mendelian inheritance of A1 and A2 alleles. Furthermore, 348 cows with complete lactation records were evaluated for 305-day mature equivalent milk and fat yields across genotypes. Although cows with the A1/A1 genotype showed numerically higher milk and fat yields, one-way ANOVA and Tukey's HSD tests revealed no statistically significant differences. These results suggest that while A2 allele selection is increasing in Taiwan, β-casein genotype does not significantly influence milk or fat production in the studied population.</p>","PeriodicalId":94175,"journal":{"name":"Polish journal of veterinary sciences","volume":"28 2","pages":"303-309"},"PeriodicalIF":1.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish journal of veterinary sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24425/pjvs.2025.154951","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

β-Casein accounts for approximately 30% of total milk protein, with the A1 and A2 variants being the most common. A1 β-casein may release β-casomorphin-7 (BCM-7) during digestion, which is associated with adverse health effects, whereas A2 β-casein does not. This study investigated the A2 allele frequency and its potential influence on milk performance in Holstein cattle in Taiwan. A total of 1,050 cows from five herds were genotyped using the GeneSeek 50K SNP chip. The A2 allele frequency ranged from 0.58 to 0.75 among herds, with an average of 0.66. Hardy-Weinberg equilibrium tests indicated no significant deviation within herds. Pedigree validation confirmed Mendelian inheritance of A1 and A2 alleles. Furthermore, 348 cows with complete lactation records were evaluated for 305-day mature equivalent milk and fat yields across genotypes. Although cows with the A1/A1 genotype showed numerically higher milk and fat yields, one-way ANOVA and Tukey's HSD tests revealed no statistically significant differences. These results suggest that while A2 allele selection is increasing in Taiwan, β-casein genotype does not significantly influence milk or fat production in the studied population.

台湾荷斯坦牛A2等位基因频率的基因检测研究。
β-酪蛋白约占牛奶蛋白总量的30%,其中A1和A2变体最为常见。A1 β-酪蛋白可能在消化过程中释放β-酪啡素-7 (BCM-7),这与不良健康影响有关,而A2 β-酪蛋白则不会。本研究旨在研究A2等位基因频率及其对台湾荷斯坦牛产奶性能的潜在影响。使用GeneSeek 50K SNP芯片对来自5个畜群的1050头奶牛进行了基因分型。A2等位基因频率分布范围为0.58 ~ 0.75,平均为0.66。Hardy-Weinberg平衡试验表明,畜群之间没有明显的偏差。系谱验证证实了A1和A2等位基因的孟德尔遗传。此外,对348头具有完整泌乳记录的奶牛进行了不同基因型的305天成熟当量产奶量和脂肪产量评估。虽然A1/A1基因型奶牛的产奶量和脂肪量在数值上较高,但单因素方差分析和Tukey’s HSD检验显示差异无统计学意义。这些结果表明,虽然A2等位基因选择在台湾增加,但β-酪蛋白基因型对研究人群的牛奶或脂肪产量没有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信