Febrile Ulceronecrotic Mucha-Habermann Disease in a 22-Month-Old Boy: A Case Presentation and Literature Review.

IF 1.1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI:10.1097/DAD.0000000000003019

Daniela Milanova-Ilieva, Georgi Bukov, Ksenia Baadji, Tsvetana Abadjieva, Kostadin Ketev, Ivanka Karavelikova, Ivan Ivanov

引用次数: 0

Abstract

Abstract: We report a 22-month-old boy with febrile ulceronecrotic Mucha-Habermann disease who presented with rapid progression of necrotic skin lesions and fever. The diagnosis was confirmed by histopathology, which revealed interface dermatitis, intraepidermal vesiculation, and erythrocyte extravasation. Immunohistochemistry revealed perivascular T-cell infiltration. Treatment with systemic corticosteroids, antibiotics, and antivirals achieved resolution. This case highlights diagnostic challenges and emphasizes the importance of integrating histopathology, immunohistochemistry, and prompt multimodal therapy.

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22月龄男童发热性溃疡性Mucha-Habermann病1例报告及文献复习。

摘要：我们报告一个22个月大的男孩患有发热性溃疡性Mucha-Habermann病，表现为皮肤坏死和发烧的快速进展。经组织病理学检查证实为界面皮炎、表皮内囊泡及红细胞外渗。免疫组化示血管周围t细胞浸润。全身性糖皮质激素、抗生素和抗病毒药物治疗得到了解决。该病例强调了诊断的挑战，并强调了组织病理学、免疫组织化学和及时多模式治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians