The Development and Toxicological Evaluation of Novel Polyurethane Materials.

IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Toxics Pub Date : 2025-06-18 DOI:10.3390/toxics13060512
Maolan Zhang, Xuanran Luo, Maocai Jiang, Yu Wen, Peng Wang, Peixing Chen, Da Sun
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引用次数: 0

Abstract

Polyurethane (PU) is widely employed in the biomedical field. As application scenarios become increasingly complex, it is essential to modify PU to meet diverse requirements. Additionally, the degradation of PU is closely linked to the sustainability of its function, with degradation products having a direct impact on adjacent tissues. In this study, a novel PU containing double bonds in its main chain was developed. We investigated the influence of various ratios of soft segment composition on the degradation performance of PU, maintaining a fixed ratio of soft to hard segments and utilizing specific synthesis methods. The structure and molecular weight of the PU were analyzed using FTIR, NMR, and GPC techniques. The results of physical and chemical performance tests indicated that an increase in polycaprolactone diol (PCL diol) content within the soft segment enhanced the mechanical properties, hydrophobicity, and degradation performance of the PU. A further assessment of the degradation toxicity of PU was carried out using zebrafish as a model organism. The findings indicated that the degradation solution of PU exhibited slight toxicity to zebrafish embryonic development over prolonged degradation periods. However, it also significantly enhanced the hatching of zebrafish embryos. In summary, the novel PU developed in this study demonstrates favorable biocompatibility, and the approach of introducing reaction sites or modifying the composition of its soft segments within the molecular structure offers a promising and effective strategy to address specific application requirements.

新型聚氨酯材料的开发与毒理学评价。
聚氨酯(PU)在生物医学领域有着广泛的应用。随着应用场景的日益复杂,需要对PU进行修改以满足不同的需求。此外,PU的降解与其功能的可持续性密切相关,降解产物对邻近组织有直接影响。本研究开发了一种主链上含有双键的新型聚氨酯。我们研究了不同比例的软段组成对PU降解性能的影响,保持固定的软段与硬段的比例,并采用特定的合成方法。利用FTIR、NMR和GPC技术分析了PU的结构和分子量。理化性能测试结果表明,软段内聚己内酯二醇(PCL diol)含量的增加提高了PU的力学性能、疏水性和降解性能。以斑马鱼为模型生物,对聚氨酯的降解毒性进行了进一步的评估。结果表明,PU降解液在较长降解时间内对斑马鱼胚胎发育具有轻微毒性。然而,它也显著提高了斑马鱼胚胎的孵化率。综上所述,本研究开发的新型聚氨酯具有良好的生物相容性,在分子结构中引入反应位点或修改其软段组成的方法为满足特定的应用需求提供了一种有前景的有效策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.
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