I Perez Counago, J M Fernandez Montenegro, S Iglesias Moreira, F Rodriguez Lorenzo, M Placer Lorenzo, P Villar Sola, E Pancorbo González, J Illade Quinteiro, L Herrero Castilla, J A Álvarez Rodríguez, B Altamira Algarra, E Gonzalez Flo, J Garcia, F Guedes, M Lopez-Garcia, S Muiños-Landin
{"title":"Improving PHB production in cyanobacteria: Modeling the optimal light regime for growth.","authors":"I Perez Counago, J M Fernandez Montenegro, S Iglesias Moreira, F Rodriguez Lorenzo, M Placer Lorenzo, P Villar Sola, E Pancorbo González, J Illade Quinteiro, L Herrero Castilla, J A Álvarez Rodríguez, B Altamira Algarra, E Gonzalez Flo, J Garcia, F Guedes, M Lopez-Garcia, S Muiños-Landin","doi":"10.1016/j.nbt.2025.05.005","DOIUrl":null,"url":null,"abstract":"<p><p>The production of bioplastics, such as polyhydroxybutyrate (PHB), using cyanobacteria offers a sustainable alternative to conventional plastics. However, achieving economically viable production requires optimizing biomass growth. This study examined four growth models: Gompertz (empirical growth), Baranyi-Roberts (biologically dependent), Monod (nutrient dependent), and Aiba (irradiance dependent). The results indicate that a light-based model more accurately describes cyanobacterial growth and shows potential for optimizing light regimes. Additionally, an estimator was proposed to assess the potential PHB yield within the given biomass. Experiments were conducted to correlate photosynthetic efficiency with biomass production, providing deeper insights into the effects of light on growth. These findings support the development of optimized cultivation strategies, ultimately improving the economic viability of cyanobacteria-based bioplastics.</p>","PeriodicalId":19190,"journal":{"name":"New biotechnology","volume":" ","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"New biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.nbt.2025.05.005","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
The production of bioplastics, such as polyhydroxybutyrate (PHB), using cyanobacteria offers a sustainable alternative to conventional plastics. However, achieving economically viable production requires optimizing biomass growth. This study examined four growth models: Gompertz (empirical growth), Baranyi-Roberts (biologically dependent), Monod (nutrient dependent), and Aiba (irradiance dependent). The results indicate that a light-based model more accurately describes cyanobacterial growth and shows potential for optimizing light regimes. Additionally, an estimator was proposed to assess the potential PHB yield within the given biomass. Experiments were conducted to correlate photosynthetic efficiency with biomass production, providing deeper insights into the effects of light on growth. These findings support the development of optimized cultivation strategies, ultimately improving the economic viability of cyanobacteria-based bioplastics.
期刊介绍:
New Biotechnology is the official journal of the European Federation of Biotechnology (EFB) and is published bimonthly. It covers both the science of biotechnology and its surrounding political, business and financial milieu. The journal publishes peer-reviewed basic research papers, authoritative reviews, feature articles and opinions in all areas of biotechnology. It reflects the full diversity of current biotechnology science, particularly those advances in research and practice that open opportunities for exploitation of knowledge, commercially or otherwise, together with news, discussion and comment on broader issues of general interest and concern. The outlook is fully international.
The scope of the journal includes the research, industrial and commercial aspects of biotechnology, in areas such as: Healthcare and Pharmaceuticals; Food and Agriculture; Biofuels; Genetic Engineering and Molecular Biology; Genomics and Synthetic Biology; Nanotechnology; Environment and Biodiversity; Biocatalysis; Bioremediation; Process engineering.