Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metabolites Pub Date : 2025-06-19 DOI:10.3390/metabo15060414
Mario Zivkovic, Marko Boban, Domagoj Vrazic, Ivan Vulic, Ivan Budimir, Nina Blazevic, Aleksandar Vcev, Marko Nikolic
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引用次数: 0

Abstract

Background: There are known associations between periodontitis and colorectal cancer, but knowledge on the connections existing between the two are not fully understood. The aim of our study was to assess prevalence and clinical severity of periodontitis in patients with localized colorectal cancer. Secondly, the dynamics of metabolic derangements, particularly glucose metabolism, insulin resistance, and diabetes mellitus were studied as well. Methods: Diagnostic procedures included endoscopies with patohistology, laboratory exams, the insulin resistance homeostatic model assessment method (HOMA index), anthropometrics, and radiology imaging. Periodontal status was evaluated by full-mouth periodontal examination. Results: A total of 79 patients with localized colorectal carcinoma, with slight male predominance of 55.7%, and an age of 65.7 ± 12.4 years participated in this study. Three-quarters of patients (73.4%; 95% CI: 63.0-82.2%) were diagnosed with periodontitis. Patients with periodontitis and colorectal cancer had significantly increased glucose levels (fasting and after oral glucose challenge), (both p < 0.05). Also, increased values of the HOMA index were found in patients with periodontitis vs. controls (without periodontitis) and colorectal cancer; 6.38 ± 5.74 vs. 3.58 ± 2.6 (p = 0.012); Spearman's Rho correlation coefficient = 0.271 (p = 0.039). There were significant differences in high-density cholesterol in patients with periodontitis vs. controls, 1.41 ± 0.28 vs. 1.23 ± 0.35 mmol/L (p = 0.016), but correlations were insignificant; Rho c.c. = 0.045 (p = 0.738). Conclusions: The most consorted connections between periodontitis and colorectal cancer were found among parameters of metabolic domain, especially glucose concentrations and insulin resistance. Further studies, which would include novel and emerging antidiabetic treatments and their effects on the prevention or control of both diseases, would be warranted.

结直肠癌患者常见于牙周炎,并可导致胰岛素抵抗的补充损害。
背景:已知牙周炎和结直肠癌之间存在关联,但两者之间存在的联系尚不完全清楚。本研究的目的是评估局部结直肠癌患者牙周炎的患病率和临床严重程度。其次,代谢紊乱的动力学,特别是葡萄糖代谢,胰岛素抵抗和糖尿病也进行了研究。方法:诊断程序包括病理组织学内窥镜检查、实验室检查、胰岛素抵抗稳态模型评估法(HOMA指数)、人体测量学和放射学成像。通过全口牙周检查评估牙周状况。结果:本研究共纳入79例局限性结直肠癌患者,男性轻微占优势,占55.7%,年龄65.7±12.4岁。四分之三的患者(73.4%;95% CI: 63.0-82.2%)被诊断为牙周炎。牙周炎和结直肠癌患者的血糖水平(空腹和口服葡萄糖激发后)均显著升高(p < 0.05)。此外,与对照组(无牙周炎)和结直肠癌患者相比,发现牙周炎患者的HOMA指数升高;6.38±5.74 vs. 3.58±2.6 (p = 0.012);Spearman’s Rho相关系数= 0.271 (p = 0.039)。牙周炎患者的高密度胆固醇与对照组比较,差异有统计学意义(1.41±0.28 vs 1.23±0.35 mmol/L) (p = 0.016),但相关性不显著;Rho c.c = 0.045 (p = 0.738)。结论:牙周炎与结直肠癌之间最密切的联系是代谢域的参数,尤其是葡萄糖浓度和胰岛素抵抗。有必要进行进一步的研究,包括新的和新兴的抗糖尿病治疗方法及其对预防或控制这两种疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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