Circulating MicroRNAs Associated with Changes in the Placenta and Their Possible Role in the Fetus During Gestational Diabetes Mellitus: A Review.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-06-03 DOI:10.3390/metabo15060367

Ninna Leslie Trejo-Gonzalez, Martin Palomar-Morales, Luis Arturo Baiza-Gutman, Guadalupe Diaz-Rosas, Clara Ortega-Camarillo, Alejandra Contreras-Ramos

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引用次数: 0

Abstract

MicroRNAs (miRs) are epigenetic regulators of several metabolic diseases, including gestational diabetes mellitus (GDM).

Objectives: Following a systematic review, we propose a pattern of key circulating miRs associated with placental changes and their potential role in the fetus.

Methods: A systematic investigation of studies published between January 2011 and July 2024 was conducted in the PubMed, ScienceDirect, Trip Database, and Wiley databases. A total of 90 articles were analyzed.

Results: Two hundred twenty-six circulating microRNAs were identified in women with GDM, and fifty miRs were validated by PCR, with miRs-16-5p, -29a-5p, and -195-5p being the most frequently reported. Interestingly, miR-16-5p was also expressed in the placenta but not in umbilical cord blood or amniotic fluid. Conversely, miR-126-3p was expressed in circulation, the placenta, umbilical cord blood, and amniotic fluid. Several reports describe high expression levels of miR-518d in maternal circulation, umbilical cord blood, and placenta. Controversial results regarding the expression of miR-29a-3p, -137, and -148a-3p were identified when comparing umbilical cord blood and the placenta.

Conclusions: In silico analyses suggest that the miR-29 family, as well as miRs-16-5p, -126-3p, -195-5p, and -518b, may be involved in alterations in the heart, brain, and kidneys in the embryo when exposed to a hyperglycemic environment.

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与胎盘变化相关的循环microrna及其在妊娠期糖尿病胎儿中的可能作用：综述

MicroRNAs （miRs）是几种代谢性疾病的表观遗传调控因子，包括妊娠糖尿病（GDM）。目的：通过系统回顾，我们提出了一种与胎盘变化相关的关键循环miRs模式及其在胎儿中的潜在作用。方法：对2011年1月至2024年7月在PubMed、ScienceDirect、Trip Database和Wiley数据库中发表的研究进行系统调查。共分析90篇文章。结果：在GDM女性中鉴定了226个循环microrna，并通过PCR验证了50个miRs，其中miRs-16-5p， -29a-5p和-195-5p是最常报道的。有趣的是，miR-16-5p也在胎盘中表达，但在脐带血或羊水中不表达。相反，miR-126-3p在循环、胎盘、脐带血和羊水中表达。一些报道描述了miR-518d在母体循环、脐带血和胎盘中的高表达水平。在比较脐带血和胎盘时，发现了关于miR-29a-3p、-137和-148a-3p表达的有争议的结果。结论：计算机分析表明，当暴露于高血糖环境时，miR-29家族以及mir -16-5p、-126-3p、-195-5p和-518b可能参与胚胎心脏、大脑和肾脏的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.