A Review on Marine Microbial Docosahexaenoic Acid Production Through Circular Economy, Fermentation Engineering, and Antioxidant Technology.

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL
Marine Drugs Pub Date : 2025-06-16 DOI:10.3390/md23060256
Fengwei Yin, Xiaolong Sun, Xi Luo, Weilong Zheng, Longfei Yin, Yingying Zhang, Yongqian Fu
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引用次数: 0

Abstract

Marine microbial-derived docosahexaenoic acid (DHA) has garnered significant attention as a sustainable and health-promoting alternative to fish oil-derived DHA. However, its industrial production from marine heterotrophic microorganisms faces challenges related to high costs and suboptimal oil quality, which hinder its broader application. This review focuses on recent strategies aimed at achieving low-cost and high-quality marine microbial DHA production, emphasizing heterotrophic systems that dominate commercial supply. Key aspects include: Fermentation optimization using waste-derived feedstocks and bioprocess engineering to enhance DHA yields; Critical refining techniques-including degumming, neutralization, decolorization, and deodorization-are analyzed for improving DHA oil purity and quality, with emphasis on process optimization to adapt to the unique biochemical properties of microbial-derived oils. Additionally, strategies for oxidative stabilization, such as antioxidant protection, are discussed to extend the shelf life and preserve the nutritional value of marine microbial DHA oil. By integrating techno-economic and biochemical perspectives, this work outlines a holistic framework to guide the industrial optimization of marine microbial-sourced DHA oil production, addressing cost and quality challenges to facilitate its large-scale application as functional foods and nutraceuticals, thereby reducing reliance on marine resources and advancing sustainable omega-3 production.

循环经济、发酵工程和抗氧化技术在海洋微生物二十二碳六烯酸生产中的应用综述
海洋微生物衍生的二十二碳六烯酸(DHA)作为一种可持续的、促进健康的鱼油衍生DHA替代品已经引起了极大的关注。然而,海洋异养微生物的工业生产面临着与高成本和不理想的油品质量相关的挑战,这阻碍了其广泛应用。本综述重点介绍了旨在实现低成本和高质量海洋微生物DHA生产的最新策略,强调了主导商业供应的异养系统。关键方面包括:利用废物来源的原料和生物工艺工程进行发酵优化,以提高DHA产量;分析了关键的精制技术,包括脱胶、中和、脱色和脱臭,以提高DHA油的纯度和质量,重点是工艺优化,以适应微生物衍生油的独特生化特性。此外,还讨论了氧化稳定策略,如抗氧化保护,以延长海洋微生物DHA油的保质期和保持其营养价值。通过整合技术经济和生物化学的观点,本研究概述了一个整体框架,以指导海洋微生物来源的DHA油生产的工业优化,解决成本和质量挑战,促进其作为功能食品和营养保健品的大规模应用,从而减少对海洋资源的依赖,促进可持续的omega-3生产。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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