Albendazole and Clorsulon in Fasciola hepatica Control: Integrated Pharmacokinetic and Flukicidal Eficacy Assessment in Sheep.

IF 1.7 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
V Chiappetta, C Cantón, C Pruzzo, C Lanusse, L Alvarez, L Ceballos
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引用次数: 0

Abstract

Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The main strategy to control fasciolosis in livestock animals, is based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine and its resistance is growing. The use of drug combinations has been proposed as a strategy to delay it. This study compares the pharmacokinetics and flukicidal efficacy of ABZ + CLOR when administered together or separately in sheep infected with F. hepatica. Enhanced systemic exposure of the ABZ sulphoxide metabolite was observed after the co-administration ABZ + CLOR compared to the ABZ alone treatment. The CLOR disposition kinetics was not affected by its co-administration with ABZ. The flukicidal clinical efficacy was 85% (ABZ), 92% (CLOR) and 100% (ABZ + CLOR), respectively. The work described here contributes to the characterization of the disposition kinetics of both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance the efficacy against F. hepatica in sheep.

阿苯达唑和克罗舒伦防治肝片形吸虫:绵羊体内综合药代动力学和杀流效果评价。
肝片形吸虫引起片形吸虫病,这是一种日益严重的人畜共患疾病,影响全世界的牲畜和人类。控制家畜片形虫病的主要策略是使用药物,如三氯苯达唑(TCBZ)、阿苯达唑(ABZ)、克罗舒伦(CLOR)、硝基尼、closantel和拉福昔尼。在人类医学中,只有TCBZ可用于控制肝念珠菌,其耐药性正在增强。使用药物组合已被提议作为一种策略来延缓它。本研究比较了ABZ + CLOR在感染肝f.s感染的绵羊体内联合或单独给药时的药代动力学和杀流效果。与单独使用ABZ治疗相比,联合使用ABZ + CLOR后,观察到ABZ亚硫酸盐代谢物的全身暴露增强。CLOR处置动力学不受其与ABZ共同给药的影响。临床杀流效果分别为85% (ABZ)、92% (CLOR)和100% (ABZ + CLOR)。本文所描述的工作有助于表征两种杀流分子的处置动力学,表明ABZ和CLOR联合治疗可能增强对绵羊肝炎的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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