Developing Bioengineered 3D-Printed Composite Scaffolds with Antimicrobial Potential for Bone Tissue Regeneration.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-06-19 DOI:10.3390/jfb16060227

Andreea Trifan, Eduard Liciu, Cristina Busuioc, Izabela-Cristina Stancu, Adela Banciu, Carmen Nicolae, Mihai Dragomir, Doru-Daniel Cristea, Rosina-Elena Sabău, David-Andrei Nițulescu, Alexandru Paraschiv

{"title":"Developing Bioengineered 3D-Printed Composite Scaffolds with Antimicrobial Potential for Bone Tissue Regeneration.","authors":"Andreea Trifan, Eduard Liciu, Cristina Busuioc, Izabela-Cristina Stancu, Adela Banciu, Carmen Nicolae, Mihai Dragomir, Doru-Daniel Cristea, Rosina-Elena Sabău, David-Andrei Nițulescu, Alexandru Paraschiv","doi":"10.3390/jfb16060227","DOIUrl":null,"url":null,"abstract":"This research activity proposes to produce composite hydrogel-bioactive glass. The primary purpose of this research is to develop and optimize 3D-printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The bioglass, a bioactive material known for its bone-bonding ability (SiO2-P2O5-CaO-Na2O), co-doped with europium and silver was synthesized and doped to improve its biological properties. This doped bioglass was then combined with a biocompatible hydrogel, chosen for its adequate cellular response and printability. The composite material was printed to form a scaffold, providing a structure that not only supports the damaged bone but also encourages osteogenesis. A variety of methods were employed to assess the rheological, compositional, and morphological characteristics of the samples: Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDS). Additionally, simulated body fluid (SBF) immersion for bioactivity monitoring and immunocytochemistry for cell viability were used to evaluate the biological response of the scaffolds.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194729/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/jfb16060227","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

This research activity proposes to produce composite hydrogel-bioactive glass. The primary purpose of this research is to develop and optimize 3D-printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The bioglass, a bioactive material known for its bone-bonding ability (SiO₂-P₂O₅-CaO-Na₂O), co-doped with europium and silver was synthesized and doped to improve its biological properties. This doped bioglass was then combined with a biocompatible hydrogel, chosen for its adequate cellular response and printability. The composite material was printed to form a scaffold, providing a structure that not only supports the damaged bone but also encourages osteogenesis. A variety of methods were employed to assess the rheological, compositional, and morphological characteristics of the samples: Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDS). Additionally, simulated body fluid (SBF) immersion for bioactivity monitoring and immunocytochemistry for cell viability were used to evaluate the biological response of the scaffolds.

查看原文本刊更多论文

开发具有抗菌潜力的生物工程3d打印复合支架用于骨组织再生。

本研究活动拟生产复合水凝胶-生物活性玻璃。本研究的主要目的是开发和优化使用掺杂生物玻璃的3d打印支架，旨在增强骨缺损的骨再生。该生物玻璃是一种具有骨结合能力的生物活性材料（SiO2-P2O5-CaO-Na2O），与铕和银共掺杂以改善其生物性能。然后将这种掺杂的生物玻璃与生物相容性水凝胶结合，选择水凝胶是因为其具有足够的细胞反应和可打印性。这种复合材料被打印成支架，提供了一种结构，不仅可以支撑受损的骨骼，还可以促进成骨。采用傅立叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和能量色散x射线光谱（EDS）等多种方法来评估样品的流变学、成分和形态特征。此外，采用模拟体液（SBF）浸泡法监测生物活性，免疫细胞化学法检测细胞活力，以评估支架的生物反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.