Mariaelena Malvasi, Pietro Mangiantini, Floriana Testa, Edoardo Trovato Battagliola, Mattia D'Andrea, Guglielmo Minozzi, Paolo Turchetti, Elena Pacella
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引用次数: 0
Abstract
Purpose: To explore the changes in the corneal endothelium in patients who receive multiple anti-vascular endothelial growth factor (anti-VEGF) or steroid injections for posterior segment pathology.
Methods: This cross-sectional study recruits subjects treated with intravitreal anti-VEGF or sustained-release dexamethasone for macular edema due to retinal vein occlusion. Corneal endothelium and corneal thickness were measured in the treated eye using a corneal endothelial microscope. The study variables include age, endothelial cell density (ECD), coefficient of variation (CV) of cell size, percentage of hexagonality (HEX%), and intraocular pressure (IOP) change 30 min after injection. These variables were analyzed using multiple linear regression analysis.
Results: A total of 108 diseased eyes were treated with a variable number (from 4 to 28) of intravitreal injections between January 2020 and December 2023. The mean total number of intravitreal injections was 12.8/eye. Multiple linear regression analysis showed an inverse relationship between ECD and age (β = -9.74, 95% confidence interval [CI] [-8.01, -10.24], P < 0.05) and total number of injections (β = -17.11, 95% CI [-16.44, -18.37], P < 0.05). An inversion relationship also exists between HEX% and age (β = -0.17, 95% CI [-0.11, -0.23], P < 0.05) and total number of injections (β = -0.45, 95% CI [-0.37, -0.54], P < 0.05). A direct relationship exists between CV and age (β =0.29, 95% CI [0.19, 0.40], P < 0.05) and total number of injections (β =0.54, 95% CI [0.45, 0.63], P < 0.05). The mean IOP difference between the injected and contralateral eye 30 min postinjection was +6.4 ± 3 mmHg (P < 0.05).
Conclusion: A greater number of intravitreal injections is associated with a lower ECD, lower HEX, and higher CV in the treated eyes.
期刊介绍:
Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.