Infectious Endophthalmitis: An Overview of Clinical Features, Microbiology Profile, and Antibiotic Sensitivity Pattern.

IF 1.2 Q3 OPHTHALMOLOGY
Journal of Current Ophthalmology Pub Date : 2025-06-05 eCollection Date: 2024-07-01 DOI:10.4103/joco.joco_67_24
Seyed Ali Tabatabaei, Ahmad Masoumi, Arash Mirzaei, Reza Mirshahi, Bita Momenaei, Faezeh Moghimpour Bijani, Ali Rashidinia, Mohammadreza Nazari, Mohammad Ahadifard, Zahra Mahdizad, Samer Habeel, Seyed Mahbod Baharnoori, Mohammad Soleimani
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引用次数: 0

Abstract

Purpose: To describe the demographic characteristics, etiology, microbiological spectrum, and antibiotic sensitivity patterns in patients with endophthalmitis.

Methods: This is a retrospective case series spanning from May 2012 to September 2018. All included patients were diagnosed with endophthalmitis and confirmed by laboratory tests. Data were collected on patient demographics, types of endophthalmitis, and microbiologic and medical records.

Results: Nine hundred ninety-two records of patients with endophthalmitis were assessed. Of the total cases, 657 patients (66.2%) were male, whereas 335 (33.8%) were female. The mean age of the patients was 57.2 ± 22.8 years and ranged from 2 to 95 years. The type of endophthalmitis was acute postcataract surgery (44.4%), posttraumatic (26.7%), chronic postcataract surgery (6.6%), endogenous (6.4%), postintravitreal injection (5.0%), keratitis-associated (3.6%), postvitrectomy (2.7%), bleb-associated (2.4%), postkeratoplasty (1.9%), and device-related (0.1%). The most frequently isolated organisms were Staphylococcus epidermidis (11.7%), followed by Streptococcus pneumoniae (5.2%) and Streptococcus viridans (5.1%). Antibiotic susceptibility testing in patients with acute postcataract surgery endophthalmitis showed variable sensitivity of S. epidermidis isolates to vancomycin (81.4%), ciprofloxacin (76.2%), and levofloxacin (75.0%). In patients with posttraumatic endophthalmitis, high rates of zone 1 injury (61.5%), traumatic cataract (67.9%), and intraocular foreign body (IOFB) (29.8%) were observed.

Conclusions: S. epidermidis is the most common causative pathogen in patients with endophthalmitis, its increasing resistance to vancomycin and fluoroquinolones may pose some challenges to the treatment of endophthalmitis in the future. Regarding the presence of IOFB, zone 1 injury, and traumatic cataracts that might be associated with an increased risk of posttraumatic endophthalmitis, it is better to consider these aspects in penetrating eye injuries.

感染性眼内炎:临床特征、微生物学概况和抗生素敏感性模式综述。
目的:描述眼内炎患者的人口学特征、病因、微生物谱和抗生素敏感性模式。方法:选取2012年5月至2018年9月的回顾性病例系列。所有患者均被诊断为眼内炎,并经实验室检查证实。收集了患者人口统计学、眼内炎类型、微生物学和医疗记录方面的数据。结果:对992例眼内炎患者进行了评价。其中男性657例(66.2%),女性335例(33.8%)。患者平均年龄57.2±22.8岁,年龄范围2 ~ 95岁。眼内炎的类型为白内障术后急性(44.4%)、外伤后(26.7%)、慢性白内障术后(6.6%)、内源性(6.4%)、玻璃体注射后(5.0%)、角膜炎相关(3.6%)、玻璃体切除术后(2.7%)、水泡相关(2.4%)、角膜移植术后(1.9%)和器械相关(0.1%)。最常见的分离菌是表皮葡萄球菌(11.7%),其次是肺炎链球菌(5.2%)和翠绿链球菌(5.1%)。急性白内障术后眼内炎患者的抗生素药敏试验显示,表皮葡萄球菌对万古霉素(81.4%)、环丙沙星(76.2%)和左氧氟沙星(75.0%)的敏感性不同。外伤性眼内炎患者1区损伤发生率高(61.5%),外伤性白内障发生率高(67.9%),眼内异物发生率高(29.8%)。结论:表皮葡萄球菌是眼内炎患者最常见的致病菌,其对万古霉素和氟喹诺酮类药物耐药性的增加可能对今后眼内炎的治疗带来一定的挑战。对于可能与创伤后眼内炎风险增加相关的IOFB、1区损伤和外伤性白内障的存在,在穿透性眼损伤中最好考虑这些方面。
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来源期刊
CiteScore
2.50
自引率
6.70%
发文量
45
审稿时长
8 weeks
期刊介绍: Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.
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