Spectroscopic Analysis of the Extracellular Matrix in Naked Mole-Rat Temporomandibular Joints.

IF 5 3区化学 Q1 POLYMER SCIENCE

Gels Pub Date : 2025-05-30 DOI:10.3390/gels11060414

Tetsuya Adachi, Hayata Imamura, Toyonari Yaji, Kentaro Mochizuki, Wenliang Zhu, Satoru Shindo, Shunichi Shibata, Keiji Adachi, Toshiro Yamamoto, Fumishige Oseko, Osam Mazda, Kyoko Miura, Toshihisa Kawai, Giuseppe Pezzotti

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引用次数: 0

Abstract

Naked mole-rats are extremely long-living rodents with a maximum lifespan of 37 years, and their cellular aging and tissue aging are almost nonexistent. Therefore, in this study, we aim to analyze the extracellular matrix of the temporomandibular joint (TMJ) of naked mole-rats at the molecular level and explore the molecules involved in anti-aging and their localization. Micro-computed tomography (CT) scans revealed increased mineral density and wear of the mandibular condyle in aged mice. Conversely, CT scans did not reveal wear of the mandibular condyle in naked mole-rats, and histological analysis did not reveal wear of the articular disk. Using various spectroscopies and artificial intelligence (AI), we found that the articular disk of naked mole-rats is composed of a cartilage-like layer with hyaluronic acid and collagen fibers with varying orientations, which is thought to have relieved mechanical stress and have protected the mandibular condyle. These results suggest that not only the amount, but also the spatial distribution of the extracellular matrix is important for the anti-aging properties of the TMJ, and may contribute to elucidating the pathology of TMJ disorders and other degenerative conditions and developing therapeutic drugs.

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裸鼹鼠大鼠颞下颌关节细胞外基质的光谱分析。

裸鼹鼠是一种寿命极长的啮齿类动物，最长寿命为37年，它们的细胞衰老和组织衰老几乎不存在。因此，本研究旨在从分子水平对裸鼹鼠颞下颌关节（TMJ）细胞外基质进行分析，探讨其抗衰老的相关分子及其定位。微计算机断层扫描（CT）显示增加矿物质密度和磨损的下颌髁在老年小鼠。相反，CT扫描未显示裸鼹鼠的下颌髁磨损，组织学分析未显示关节盘磨损。利用各种光谱和人工智能（AI），我们发现裸鼹鼠的关节盘是由一个软骨样层组成的，透明质酸和胶原纤维具有不同的取向，被认为可以减轻机械应力并保护下颌髁。这些结果表明，细胞外基质的数量和空间分布不仅对TMJ的抗衰老特性有重要影响，而且可能有助于阐明TMJ疾病和其他退行性疾病的病理，并有助于开发治疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.