Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats.

IF 2.6 3区医学 Q2 BEHAVIORAL SCIENCES

Frontiers in Behavioral Neuroscience Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI:10.3389/fnbeh.2025.1603564

Alixandria T Mascarin, Ava M Mac, Srinivasu Kallakuri, Mark K Greenwald, Shane A Perrine

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引用次数: 0

Abstract

Introduction: Misuse of drugs and natural rewards, such as food, share common neural pathways and comparably influence behavioral consequences. Food-restriction enhances drug-taking and drug-seeking behaviors in animals, but the effect of food-restriction on cocaine self-administration and cocaine-seeking in both sexes has not been well characterized.

Methods: Therefore, the present study investigated differences between food-restricted vs. ad libitum-feeding male and female Wistar rats on the acquisition of cocaine self-administration and cue-induced reinstatement of cocaine-seeking.

Results: Food access sex-dependently altered the acquisition of cocaine self-administration such that food-restricted females, but not males, displayed an escalated intake behavior over time. Only food-restricted females differed significantly between active and inactive lever pressing during the reinstatement of cocaine-seeking session.

Discussion: Taken together, these results suggest that food-restriction sex-dependently improves learning of cocaine self-administration that persists to alter cocaine-seeking behavior following abstinence.

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食物限制对大鼠可卡因自我给药和可卡因寻找的性别依赖效应。

滥用药物和自然奖励（如食物）共享共同的神经通路，并对行为后果产生类似的影响。限制食物可增强动物的吸毒和觅药行为，但限制食物对两性可卡因自我给药和觅药行为的影响尚不清楚。方法：因此，本研究研究了限制进食与自由进食的雄性和雌性Wistar大鼠在获得可卡因自我给药和线索诱导的可卡因寻求恢复方面的差异。结果：食物获取的性别依赖性改变了可卡因自我给药的获得，因此，食物受限的雌性，而不是雄性，随着时间的推移，表现出逐渐升级的摄入行为。在恢复可卡因寻找过程中，只有食物限制的雌性在主动和不主动按压杠杆之间存在显著差异。讨论：综上所述，这些结果表明，限制食物的性别依赖性改善了可卡因自我给药的学习，这种学习持续改变戒断后的可卡因寻求行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

4.70

自引率

3.30%

发文量

506

审稿时长

6-12 weeks

期刊介绍： Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.