Advances in cell spheroid technology towards complex tissue formation guided by microfabrication and biomaterial innovations.

IF 8.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Rabi Ibrahim Saleh, Chaenyung Cha
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引用次数: 0

Abstract

Spheroids have become a de facto model three-dimensional tissue for studying various biological phenomena. While the technology to produce spheroids has become highly accessible and is routinely used by researchers, it has quite a long history, going through successive advances incorporating various scientific and engineering principles to acquire efficiency, accuracy, and high-throughput capability. More recently, the spheroid technology is advancing towards recapitulating complex physiological features, especially introducing extracellular components via biomaterials to more accurately portray tissue microenvironment. This review introduces and chronicles the advancement in spheroid technology in historical perspective, highlighting the key attributes of various techniques with notable examples. The spheroid technology is for convenience divided into three different generations, based on the era and the level of technological sophistication.

微加工和生物材料创新引导下复杂组织形成的细胞球体技术进展。
球体已经成为研究各种生物现象的实际模型三维(3D)组织。虽然生产球体的技术已经变得非常容易获得,并且经常被研究人员使用,但它有相当长的历史,经历了结合各种科学和工程原理的连续进步,以获得效率、准确性和高通量能力。最近,球体技术正朝着再现复杂生理特征的方向发展,特别是通过生物材料引入细胞外成分,以更准确地描绘组织微环境。这篇综述从历史的角度介绍和记录了球体技术的进步,并以显著的例子突出了各种技术的关键属性。为方便起见,球体技术根据时代和技术成熟程度分为三代。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biofabrication
Biofabrication ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
17.40
自引率
3.30%
发文量
118
审稿时长
2 months
期刊介绍: Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).
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