Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids.

IF 3.4 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY
Lei Feng, Liugen Xu, Junhao Wen, Minghai Zhao, Amjad Ali, Naushad Ahmad, Jianwei Lu, Li Guo
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引用次数: 0

Abstract

Developing safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic the amphiphilic characteristics of threonine were prepared. The effects of chain length and molecular topology on antifreeze properties were systematically investigated. Both ice recrystallization inhibition (IRI) and ice crystal growth suppression improved with increasing chain length, and star-shaped peptoids exhibited superior performance. Notably, the star-shaped peptoid S-(A6)3 demonstrated excellent antifreeze activity and low cytotoxicity, highlighting its promise as a novel, non-toxic alternative to conventional cryoprotectants like DMSO. These findings provide valuable insight into the structure-property relationship of peptoids for cryopreservation applications.

仿生线性和星形肽体拓扑相关的防冻性能。
开发安全高效的冷冻保护剂是生物医学应用中有效低温保存的关键。受天然抗冻蛋白(AFPs)的启发,制备了一系列具有异丙醇侧链的线性和星形肽,以模拟苏氨酸的两亲性特征。系统地研究了链长和分子拓扑结构对抗冻性能的影响。冰重结晶抑制(IRI)和冰晶生长抑制均随链长增加而增强,星形肽表现出较好的抑制效果。值得注意的是,星形肽S-(A6)3表现出优异的抗冻活性和低细胞毒性,突显了其作为DMSO等传统冷冻保护剂的新型无毒替代品的前景。这些发现为类肽的结构-性质关系提供了有价值的见解,可用于冷冻保存。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomimetics
Biomimetics Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
3.50
自引率
11.10%
发文量
189
审稿时长
11 weeks
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