Real World Side-Effects of Dupilumab: A Narrative Review

IF 1.8 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-06-25 DOI:10.1111/ajd.14557

Conor Larney, Peter Foley, Jason Wu, Benjamin S. Daniel

引用次数: 0

Abstract

Real-world use of dupilumab has unveiled a spectrum of side effects that were not fully appreciated in initial clinical trials. While dupilumab remains a highly effective treatment for atopic dermatitis, clinicians must be aware of real-world adverse effects including ocular complications, inflammatory arthritis, psoriasiform eruptions and head and neck dermatitis; as well as reported associations including cutaneous T-cell lymphoma, alopecia areata, vitiligo and weight gain.

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杜匹单抗在现实世界中的副作用：一个叙述性的回顾。

dupilumab在现实世界的使用已经揭示了一系列的副作用，这些副作用在最初的临床试验中没有得到充分的认识。虽然杜匹单抗仍然是特应性皮炎的一种非常有效的治疗方法，但临床医生必须意识到现实世界的不良反应，包括眼部并发症、炎症性关节炎、牛皮癣样皮疹和头颈部皮炎；以及与皮肤t细胞淋巴瘤、斑秃、白癜风和体重增加有关的报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.